Hepatic detoxification activity of Olea europaea L. leaves against paracetamol-induced liver toxicity in rats

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Research Paper 01/01/2021
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Hepatic detoxification activity of Olea europaea L. leaves against paracetamol-induced liver toxicity in rats

Reem Abdul-Al Raheem Alsaad
Int. J. Biosci.18( 1), 178-184, January 2021.
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Hepatotoxicity is a critical impairment of liver caused by different reasons such as overdoses of some drugs like acetaminophen (paracetamol). The Olea europaea L. leaves have multiple pharmacological effects and may use as hepatic detoxification. 100 g of leaves powder has been macerated with 1000 ml absolute ethanol for 48 h., induction of hepatotoxicity in rats was done using 400 mg\kg of paracetamol, 25 mg/kg of silymarin was used as standard drug. Different concentrations ranged between 250, 500, 1000 and 2000 mg\kg of ethanolic extract were used to detoxing from rats liver. Liver enzymes (ALT, AST and ALP) have been measured after 24 h. of treatment. The results showed that the high level of (ALT, AST and ALP) has been reoptimized after treatment with different concentration. However, the concentration (2000 mg\kg) exhibited to regulate the liver enzyme better than other concentrations. We found that ethanol extract of Olea europaea L. leaves could act as hepatic detoxification agent in rats.


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