Hepatitis treatment potential of Echeveria elegans extract in Mus musculus var. albino with CCl4-induced liver injury

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Research Paper 04/05/2024
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Hepatitis treatment potential of Echeveria elegans extract in Mus musculus var. albino with CCl4-induced liver injury

Bao-Ngan Dang, Thi-Phuong-Nga Pham, Nguyen-Hoang-Uyen Tran, Hoang-Gia-Lac Vo,Van-Thanh Vo
Int. J. Biosci.24( 5), 50-57, May 2024.
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This study investigated the potential hepatoprotective effects of Echeveria elegans extract against CCl4-induced liver injury in albino mice (Mus musculus var. albino). Mice were divided into 6 groups: control, E. elegans extract 100% (SD100), CCl4, silymarin (standard drug), CCl4 + E. elegans extract 25% (CCl4.SD25), and CCl4 + E. elegans extract 50% (CCl4.SD50). After 6 weeks, growth performance parameters like weight gain, average daily gain, and specific growth rate were measured. Serum levels of AST, ALT, and bilirubin were analyzed as biochemical indicators of liver function. Histological examination of liver tissues was also performed. The CCl4 group showed signs of liver injury like increased liver size, pale color, and white spots. However, the E. elegans extract groups, especially CCl4.SD50 demonstrated significant improvement in gross liver morphology and histological architecture, comparable to the silymarin group. While serum enzyme levels did not differ significantly between groups.The CCl4.SD50 group showed a greater reduction in bilirubin levels than silymarin. The findings suggest that E. elegans extract, particularly at 50% concentration, exhibits promising hepatoprotective potential against CCl4-induced chronic liver injury, warranting further investigation into its therapeutic efficacy and mechanism of action.


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