Int. J. Biosci.15( 1), 341-352, July 2019
Drug detoxification functioning of liver exposes it to a variety of toxic metabolites and the damage due to toxins can lead to liver diseases. However, treatment options for liver pathologies are very limited in conventional medicines, therefore, the focus has been shifted more towards alternatives routes to restore the functions of liver. Coffee is a widely consumed beverage that has exhibited improvement in liver physiology. This study was carried out to investigate the hepatoprotective effects of Arabica coffee beans by in New Zealand rabbits that exhibited drug toxicity following an overdose of paracetamol via oral ingestion. To evaluate whether coffee offers hepatoprotection at earliest hour of its consumption, a group of animals received co-treatment of Arabica coffee beans and paracetamol. Another group received paracetamol only. A control group of animals was also included for comparison. Liver function, lipid profile, renal efficiency and CYP2E1 gene expression of all the animals in each group were estimated. Arabica coffee beans showed a decrease in ALT and ALP levels and restoration of ferritin. Lipid profile tests displayed that coffee group showed a reduction in TL and TC level, TG were elevated and LDL were restored and no change was found for HDL levels. Coffee consumption was found to increase the urea and creatinine levels. Upregulated gene expression of CYP2E1 indicated liver injury in paracetamol group whereas coffee significantly downregulated it. Thus, coffee beans exhibited hepatoprotective actions along with the restoration of lipid profile in acute liver injury animal models of 4 hour.
Adewusi E, Afolayan AJ. 2010. A review of natural products with hepatoprotective activity. Journal of medicinal plants research 4, 1318-1334. http://dx.doi.org/10.5897/JMPR09.472
Alshammari GM, Balakrishnan A, Al-Khalifa A. 2017. Antioxidant effect of Arabian coffee (Coffea arabica L) blended with cloves or cardamom in high-fat diet-fed C57BL/6J mice. Tropical Journal of Pharmaceutical Research 16, 1545-1552. http://dx.doi.org/10.4314/tjpr.v16i7.12
Anastasiou OE, Kälsch J, Hakmouni M, Kucukoglu O, Heider D, Korth J, Manka P, Sowa JP, Bechmann L, Saner FH, Paul A, Gerken G, Baba HA, Canbay A. 2017. Low transferrin and high ferritin concentrations are associated with worse outcome in acute liver failure. Liver International 37, 1032-1041. https://doi.org/10.1111/liv.13369
Aro A, Teirilä J, Gref CG. 1990. Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled, non-filtered coffee. Atherosclerosis 83, 257-261. https://doi.org/10.1016/0021-9150(90)90171-E
Batista MN, Carneiro BM, Braga ACS, Rahal P. 2014.Caffeine inhibits hepatitis C virus replication in vitro. Archives of Virology 160, 399-407. http://dx.doi.org/10.1007/s00705-014-2302-1
Bhawna S, Kumar SU. 2009. Hepatoprotective activity of some indigenous plants. International Journa of PharmTech Research 4, 1330-1334.
Burtis CA, Ashwood ER, Bruns DE. 2012. Preface. In, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Elsevier, City, p. xvi.
Cai L, Ma D, Zhang Y, Liu Z, Wang P. 2012. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition 66, 872-877. https://doi.org/10.1038/ejcn.2012.68
Casiglia E, Spolaore P, Inocchio G, Ambrosio B. 1993. Unexpected effects of coffee consumption on liver enzymes. European Journal of Epidemiology 9, 293-297. https://doi.org/10.1007/BF00146266
Corrêa TAF, Rogero MM, Mioto BM, Tarasoutchi D, Tuda VL, César LAM, Torres EAFS. 2013. Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial. Nutrition 29, 977-981. https://doi.org/10.1016/j.nut.2013.01.003
Davidson CS, Trey C. 2007. Hepatology: A Textbook of Liver Disease. Edited by David Zakim and Thomas B. Boyer. 1,318 pp. illustrated. Philadelphia: W. B. Saunders, 1982. $95.00. Hepatology 3, 1041-1041. https://doi.org/10.1002/hep.1840030.626
Eastham EJ, Bell JI, Douglas AP. 1976. Serum ferritin levels in acute hepatocellular damage from paracetamol overdosage. British Medical Journal 1, 750-751. http://dx.doi.org10.1136/bmj.1.6012750-a
Emmanuel A, Majesty D, Benjamin A, Peter A, Princess U. 2017. Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model. Advances in Biology 2017, 1-8. https://doi.org/10.1155/2017/9303276
Gardner C, Laskin J, Dambach D, Sacco M, Durham S, Bruno M, Cohen S, Gordon M, Gerecke D, Zhou P. 2002. Reduced Hepatotoxicity of Acetaminophen in Mice Lacking Inducible Nitric Oxide Synthase: Potential Role of Tumor Necrosis Factor-α and Interleukin-10. Toxicology and Applied Pharmacology 184, 27-36. https://doi.org/10.1006/taap.2002.9474
Heckers H, Göbel U, Kleppel U. 1994. End of the coffee mystery: diterpene alcohols raise serum low-density lipoprotein cholesterol and triglyceride levels. Journal of Internal Medicine 235, 192-193. https://doi.org/10.1111/j.1365-2796.1994.tb01058.x
Honjo S. 2001. Coffee consumption and serum aminotransferases in middle-aged Japanese men. Journal of Clinical Epidemiology 54, 823-829. https://doi.org/10.1016/S0895-4356(01)00344-4
Kaplowitz N. 2001. Drug-Induced Liver Disorders. Drug Safety 24, 483-490.
Kher K, Makker S. 1987. Acute renal failure due to acetaminophen ingestion without concurrent hepatotoxicity. The American Journal of Medicine 82, 1280-1281.
Kim SK, Shin MH, Sugimoto K, Kim SR, Imoto S, Kim KI, Taniguchi M, Oh HK, Yano Y, Hayashi Y, Kudo M. 2016. Coffee Intake and Liver Enzyme Association in Korean Immigrants and Japanese: A Comprehensive Cross-Sectional Study. Digestive Diseases 34, 665-670. https://doi.org/10.1159/000448832
Kolawole O, Akiibinu M, Akanji M. 2014. Assessment of the effect of aqueous extract of calyx of Hibiscus sabdariffa on some biochemical indices of renal function in rats. International Journal of Pharma Sciences 4, 587-590.
Lee C. 2000. Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation. Clinica Chimica Acta 295, 141-154. https://doi.org/10.1016/S0009-8981(00)00201-1
Liu F, Wang X, Wu G, Chen L, Hu P, Ren H, Hu H. 2015. Coffee Consumption Decreases Risks for Hepatic Fibrosis and Cirrhosis: A Meta-Analysis. PLOS ONE 10, e0142457. https://doi.org/10.1371/journal.pone.0142457
Maurin O, Davis AP, Chester M, Mvungi EF, Jaufeerally-Fakim Y, Fay MF. 2007. Towards a Phylogeny for Coffea (Rubiaceae): Identifying Well-supported Lineages Based on Nuclear and Plastid DNA Sequences. Annals of Botany 100, 1565-1583. https://doi.org/10.1093/aob/mcm257
McGill MR, Jaeschke H. 2013. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research 30, 2174-2187.
McNally PR. 2010. Drug-Induced Liver Disease. In, GI/Liver Secrets. Elsevier, City, p 180-185.
Molloy JW, Calcagno CJ, Williams CD, Jones FJ, Torres DM, Harrison SA. 2011. Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis. Hepatology 55, 429-436. https://doi.org/10.1002/hep.24731
Mushtaq A, Ahmad M, Jabeen Q, Saqib A, Wajid M, Akram A. 2014. Hepatoprotective investigations of Cuminum cyminum dried seeds in nimesulide intoxicated albino rats by phytochemical and biochemical methods. International Journal of Pharmacy and Pharmaceutical Sciences 6, 506-510.
Nakanishi N, Nakamura K, Suzuki K, Tatara K. 2000. Effects of Coffee Consumption against the Development of Liver Dysfunction. A 4-Year Follow-Up Study of Middle-Aged Japanese Male Office Workers. Industrial Health 38, 99-102. https://doi.org/10.2486/indhealth.38.99
Pashmforoosh M, Rezaie A, Haghi-Karamallah M, Fazlara A, Shahriari A, Najafzadeh H. 2015. Effects of caffeine on renal toxicity induced by diethylnitrosamine. Zahedan Journal of Research in Medical Sciences 17, 7-9.
Pedraza-Chaverrı́ J, Barrera D, Hernández-Pando R, Medina-Campos ON, Cruz C, Murguı́a F, Juárez-Nicolás C, Correa-Rotter R, Torres N, Tovar AR. 2004. Soy protein diet ameliorates renal nitrotyrosine formation and chronic nephropathy induced by puromycin aminonucleoside. Life Sciences 74, 987-999. https://doi.org/10.1016/j.lfs.2003.07.045
Peng HM, Coon MJ. 1998. Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone. Molecular Pharmacology 54, 740-747.
Pham T, Lu S, Kaplowitz N. 1997. Acetaminophen hepatotoxicity. Gastrointestinal emergencies. Baltimore: Williams and Wilkins, 371-388.
Prescott LF. 1980. Kinetics and metabolism of paracetamol and phenacetin. British Journal of Clinical Pharmacology 10, 291S-298S. https://doi.org/10.1111/j.13652125.1980.tb01812.x
Ratnayake WMN, Hollywood R, O’Grady E, Stavric B. 1993. Lipid content and composition of coffee brews prepared by different methods. Food and Chemical Toxicology 31, 263-269. https://doi.org/10.1016/0278-6915(93)90076-B
Ruhl CE, Everhart JE. 2005. Coffee and Tea Consumption Are Associated With a Lower Incidence of Chronic Liver Disease in the United States. Gastroenterology 129, 1928-1936. https://doi.org/10.1053/j.gastro.2005.08.056
Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. 2004. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transplantation 10, 1018-1023. https://doi.org/10.1002/lt.20204
Sabina EP, Pragasam SJ, Kumar S, Rasool M. 2011. 6-Gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice. Journal of Chinese Integrative Medicine 9, 1264-1269.
Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE. 2015. Association of Coffee Intake With Reduced Incidence of Liver Cancer and Death From Chronic Liver Disease in the US Multiethnic Cohort. Gastroenterology 148, 118-125. https://doi.org/10.1053/j.gastro.2014.10.005
Sinclair JF, Szakacs JG, Wood SG, Kostrubsky VE, Jeffery EH, Wrighton SA, Bement WJ, Wright D, Sinclair PR. 2000. Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol. Biochemical Pharmacology 59, 445-454. https://doi.org/10.1016/S0006-2952(99)00349-4
Smith DA, Schmid EF. 2006. Drug withdrawals and the lessons within. Current Opinion in Drug Discovery & Development 9, 38-46.
Snawder JE, Roe AL, Benson RW, Roberts DW. 1994. Loss of CYP2E1 and CYP1A2 Activity as a Function of Acetaminophen Dose: Relation to Toxicity. Biochemical and Biophysical Research Communications 203, 532-539. https://doi.org/10.1006/bbrc.1994.2215
Talke H, Schubert GE. 1965. Enzymatische Harnstoffbestimmung in Blut und Serum im optischen Test nachWarburg. Klinische Wochenschrift 43, 174-175. https://doi.org/10.1007/BF01484513
Thelle DS, Arnesen E, Førde OH. 1983. The Tromsø Heart Study. New England Journal of Medicine 308, 1454-1457. http://dx.doi.org/10.1056/NEJM198306163082405
Toth PP. 2005. The “Good Cholesterol”. Circulation 111. https://doi.org/10.1161/01.
Urgert R, Essed N, Van der Weg G, Kosmeijer-Schuil TG, Katan MB. 1997. Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. The American Journal of Clinical Nutrition 65, 519-524. https://doi.org/10.1093/ajcn/65.2.519
Weusten-Van der Wouw, M Katan, M Viani R, Huggett A, Liardon R, Lund-Larsen P, Thelle D, Ahola I, Aro A. 1994. Identity of the cholesterol-raising factor from boiled coffee and its effects on liver function enzymes. Journal of lipid research 35, 721-733.
Yang D, Lin S, Yang D, Wei L, Shang W. 2012. Effects of Short- and Long-Term Hypercholesterolemia on Contrast-Induced Acute Kidney Injury. American Journal of Nephrology 35, 80-89. https://doi.org/10.1159/000335077
Zilva JF, Pannall PR, Mayne PD. 1975. Clinical chemistry in diagnosis and treatment. Lloyd-Luke London.