Paper Details

High sensitive C-reactive protein in adult obese men with and without type II diabetes

Alireza Shahsavar, Mohamadzaman Kaboli, Bahman Samiee, Akram Ezabadi

DOI: https://dx.doi.org/10.12692/ijb/4.4.156-161

Int. J. Biosci. 4(4), 156-161. February, 2014. (PDF)

Abstract:

C-reactive protein (CRP), an acute phase proteins, is associated with obesity and related diseases. The objective of present study was to determine difference in serum CRP between adult obese men with type II diabetes and healthy obese men. Fasting blood samples were collected in type 2 diabetes men (n= 12) and non-diabetes men (n= 12) matched for age and body mass index that participated in present study by accessible sampling. Blood samples used to determine and compare serum CRP, insulin and glucose concentration between two groups. Independent student t test was used for between groups comparison. No significant differences in anthropometrical markers between diabetic and non-diabetic group (p ≥ 0.05). There were no differences in serum CRP concentrations between diabetic and non-diabetic subjects (p= 0.402). Fasting glucose (p < 0.001) and insulin resistance (p < 0.001) were higher in diabetic group than in non-diabetic subjects. In conclusion we can say that serum CRP as an inflammatory cytokine does not influence by diabetic state. Indeed, presence of diabetes does not affect serum CRP in obese men. Further studies are needed to clarify possible mechanisms by which diabetes can be affect inflammatory profile.