Histologic sequelae following exposure to turmeric extract on wistar rats ovary and uterus

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Research Paper 14/02/2023
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Histologic sequelae following exposure to turmeric extract on wistar rats ovary and uterus

Ahama Endurance Efe, Onyilo Peace Omewomano, Agbamu Emmanuel, Odokuma Emmanuel Igho, Ossai Ijeoma Favour, Ogorugba Clinton Oroghene
Int. J. Biomol. & Biomed.16( 1), 13-20, February 2023.
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Abstract

The regular and single use of turmeric in reference to the reproductive system following several review is conflicting, and its effect has not been fully ascertained. The study therefore espoused the histologic sequelae following exposure to turmeric extract on wistar rats ovary and uterus. Ethical clearance was sought from the Research and Ethics Committee in the Faculty of Basic Medical Sciences of the Delta State University prior to the commencement of this research. 24 wistar rats divided into 4 groups of 6 rats each. Group A was the control group while groups B, C and D were the treated groups that received 500, 1000 and 1500mg/kg of turmeric extract respectively. Animals were also sub-sectioned, labeled accordingly into 7th, 14th and 21st days respectively for easy identification and treatment or administration. At the end of each experimental days, animals were weighed and euthanized by cervical dislocation. Ovaries and uterus were dissected and fixed in 10% formal saline solution, following regulated histologic procedures. Prepared Slides were viewed using a digital microscope. The micrographs obtained revealed deleterious effect on the histology and cytology of the ovary and uterus following treatment of turmeric. The observed histological distortions to the ovary and uterus have most likely arisen from repeated exposure to tumeric extract; this has proven turmeric to be an harmful substance to the female reproductive system especially women of child bearing age and the regular and continuous consumption of these agent should be regulated.

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