Honey as a topical antibacterial agent for treatment of superficial infected wounds

Paper Details

Research Paper 01/07/2019
Views (264) Download (14)
current_issue_feature_image
publication_file

Honey as a topical antibacterial agent for treatment of superficial infected wounds

Muhammad Owais Ahmed Khan, Khan Usmanghani, Abdul Hannan, Noor-Us-Sabah, Ejaz Mohiuddin, Syed Zahoor-Ul- Hassan Zaidi
Int. J. Biosci.15( 1), 564-571, July 2019.
Certificate: IJB 2019 [Generate Certificate]

Abstract

The excessive use of antibiotics has led to the ever increasing emergence of resistant strains. Honey as a natural source possessing antibacterial activity could be a good alternative to antibiotics. It is a cost effective natural remedy, easily available and has longer shelf life. It is a single product having antibacterial, anti-inflammatory, antiseptic and analgesic properties, all in one. This study aims to find an efficacious alternative to antibiotics used for the treatment of infected wounds which would be much cost effective and do not result in development of resistant organisms. A randomized controlled trial for healing of infected acute partial thickness skin wounds was conducted on 196 subjects treated with Honey in the test group and Triple Antibiotic Ointment with Pain Reliever in the control group. The difference between the baseline parameters among the two groups was statistically insignificant. Bates-Jensen Wound Assessment Tool was used for the assessment of wound healing. The level of the significance (α) was set to be 0.05. Results with p-value less than 0.05 were considered statistically significant. Rapid healing time was noted for honey as compared to the Triple Antibiotic Ointment with Pain Reliever. The mean healing time was 14.06 days for honey while 15.65 days for Triple Antibiotic Ointment. There was an appreciable difference in the reduction of size among the test group at day 5 (p-value of 0.028) and at day 10 (p-value of 0.007). This research demonstrates that honey could be an effective alternative for the treatment of infected skin wounds.

VIEWS 11

Al-Jabri AA. 2005. Honey, milk and antibiotics. African Journal of Biotechnology 4(13), p. 1580-7.

Baghel PS, Mathur RK, Randa R. 2009. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian Journal of Plastic Surgery 42(2), p. 176-81.

Bessa LJ, Fazii P, Di Giulio M, Cellini L. 2015. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: some remarks about wound infection. International Wound Journal  12(1), p. 47-52.

Biswas ABM, Hurst C, Gruessner R, Armstrong D, Rilo H. 2010. Use of sugar on the healing of diabetic ulcers: a review. Journal of Diabetes Science and Technology 4(5), p. 1139-45.

Cutting KF. 2018. The current burden of infected wounds. British Journal of Healthcare Management 22(9), p. 436-8.

Esmon CT. 2004. Crosstalk between inflammation and thrombosis. Maturitas 47(4), p. 305-14.

Garten AJ. 2017 Assessing And Monitoring Wound Progression With The Bates-Jensen Wound Assessment Tool.

Gethin G. 2009. Manuka honey vs. hydrogel–a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. Journal of Clinical Nursing 18(3), p. 466-74.

Giacometti ACO, Schimizzi AM, Del Prete MS, Barchiesi F, D’Errico MM, Petrelli E, Scalise G. 2000. Epidemiology and Microbiology of Surgical Wound Infections. Journal of Clinical Microbiology 38(2).

Huddleston H. 2014. Obtaining a wound swab culture specimen. Nursing 44(7).

Ingle JL, Polindern K. 2006. Wound healing with honey – a randomised controlled trial. South African Medical Jounal 96(9), p. 831-5.

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. 2015. Honey as a topical treatment for wounds. Cochrane Database of Systematic Reviews 3.

Majtan JKP, Majtan T, Walls AF, Klaudiny J. 2010. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Experimental Dermatology 19(8), p. 73-9.

Malik KI, Aslam A. 2010. Honey compared with silver sulphadiazine in the treatment of superficial partial-thickness burns. International Wound Journal 7(5), p. 413-7.

Mashhood AA, Sami AN. 2006. Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. Journal of Pakistan Association of Dermatologists 16, p. 14-9.

Memon AR, Imdad A, Memon GA. 2005. Therapeutic effects of honey versus silver sulphadiazine in the management of burn injuries. Journal of Liaquat University of Medical and Health Sciences 4(3), p 100-4.

Molan PC, Rhodes T. 2015. Honey: A Biologic Wound Dressing. Wounds 27(6), p. 141-51.

Molan PC. 2002. Re-introducing honey in the management of wounds and ulcers – theory and practice. Ostomy Wound Management 48(11), p. 28-40.

Molan PC. 2009. Debridement of wounds with honey. Journal of Wound Technology 5, p. 12-7.

Struelens MJ. 2006. Rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) and patient management. Clinical Microbiology and Infection 12, p. 23-6.

Subrahmanyam M. 1991. Topical application of honey in treatment of burns. The British journal of Surgery 78(4), p. 497-8.

Subrahmanyam M. 1993. Honey impregnated gauze versus polyurethane film (OpSiteR) in the treatment of burns – a prospective randomised study. British Journal of Plastic Surgery 46, p. 322-3.

Subrahmanyam M. 1994. Honey-impregnated gauze versus amniotic membrane in the treatment of burns Journal of the International Society for Burn Injuries 20(4), p. 331-3.

Subrahmanyam M. 1996. Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. Journal of the International Society for Burn Injuries 22(6), p. 491-3.

Subrahmanyam M. 1998. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Journal of the International Society for Burn Injuries 24(2).

Tasleem S, Khan SA, Hashimi K. 2011. Honey ointment’: A natural remedy of skin wound infections. Journal of Ayub Medical College 23(2).

Tasleem S, Khan SA, Hashmi K. 2013. Efficacy of newly formulated ointment containing 20% active antimicrobial honey in treatment of burn wound infections. Journal of Ayub Medical College 25, p. 145-8.

WHO. 2013. Traditional Medicine Strategy 2014-2023. Available from: http://www.who.int /medicines/publications/traditional/trmstrategy1423/en/. Cited on 23rd May 2019