Human serum resistin is related to homeostasis model assessment of insulin resistance in healthy people
Paper Details
Human serum resistin is related to homeostasis model assessment of insulin resistance in healthy people
Abstract
Resistin, an inflammation cytokine secreted by adipose tissue, has been demonstrated to increase insulin resistance. However, its role in human remains controversial. This study aimed to evaluate relationship between serums resistin with insulin resistance in a group of healthy adult men. For this purpose, we measured fasting serum resistin, glucose and insulin after an overnight fast in thirty nine sedentary adult men aged 38 – 43 years with body mass index between 26 – 32 kg/m2. All re participants were healthy without any chronic diseases particularly type II diabetic. Insulin resistance was calculated using fasting insulin and glucose concentration. A Pearson correlation was used to establish the relationship between serums resistin with the other variables. The statistical finding showed a positive significant relation between serum resistin and insulin resistance index (p = 0.033). A borderline signigcant positive association was observed between serum resistin and fasting glucose (p = 0.048). But insulin was not related with serum resistin (p = 0.211). Although serum resistin levels were not related to insulin, this data showed that resistin may be affect glucose and insulin resistance that is likely by mechanisms independent of insulin. Further studies are necessary to elucidate the significance of serum resistin concentration in insulin resistance pathophysiology.
Bajaj M, Suraamornkul S, Hardies LJ, Pratipanawatr T, DeFronzo RA. 2004. Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients. Int J Obes Relat Metab Disord 28(6), 783–9.
Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y. 2004. Regulation of fasted blood glucose by resistin. Science 303, 1195-1198.
Brown JE, Onyango DJ, Dunmore SJ. 2007. Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells. FEBS Lett 581(17), 3273-6.
Chanchay S, Tungtrongchitr R, Harnroongroj T, Phonrat B, Rungseesakorn O, Paksanont S et al. 2006. Plasma resistin, insulin concentration in non-diabetic and diabetic, overweight/obese Thai. Int J Vitam Nutr Res 76(3), 125-31.
Feng Liu, Hong-Qi Fan, Jie Qiu, Bin Wang, Min Zhang, Nan Gu et al. 2008. A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance. World J Gastroenterol 14(1), 95-100.
Fujinami A, Obayashi H, Ohta K, Ichimura T, Nishimura M, Matsui H. 2004. Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes. Clin Chim Acta 339(1–2), 57–63.
Haugen F, Jorgensen A, Drevon CA, Trayhurn P. 2001. Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507, 105-108.
Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E. 2004. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocr Metab 89(4), 1844–8.
Kershaw E, Flier J. 2004. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89(6), 2548–2556.
Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML. 1998.Evidence for involvement of the proteasome complex (26S) and NFκB in IL-1β-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 47(4), 583–591.
Lu HL, Wang HW, Wen Y, Zhang MX, Lin HH. 2006. Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes. World J Gastroenterol 12(11), 1747-51.
Marita AR, Sarkar JA, Rane S. 2005. Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: Study from Mumbai, Western India. Molecular and Cellular Biochemistry 275, 143–151.
McTernan PG, Fisher FM, valsamakis G, Chetty R, Harte A, McTernan CL. 2003. Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin EndocrMetab 88(12), 6098–106.
Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. 2004. Reduced beta-cell mass and altered glucose sensing impairs insulin-secretory function in betaIRKO mice. Am. J. Physiol. Endocrinol. Metab 286(1), 41-49
Palanivel R, Maida A, Liu Y, Sweeney G. 2006. Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin. Diabetologia 49, 183-190.
Palanivel R, Sweeney G. 2005. Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Lett 579, 5049-5054.
Pfutzner A, Langenfeld M, Kunt T, Lobig M, Forst T. 2003. Evaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance. Clin Lab Med 49(11-12), 571-6.
Pravenec M, Kazdova L, Cahova M, Landa V, Zidek V , Mlejnek P. 2006. Fat-specifi c transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterifi cation. Int J Obes Lond 30, 1157-1159.
Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R , PajvaniU . 2004. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 53, 1671-1679.
RajalaMW, Obici S, Scherer PE, Rossetti L. 2003. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111(2), 225–30.
Stejskal D, Adamovská S, Bartek J, Juráková R, Prosková J. 2003. Resistin – concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147(1), 63-9.
Steppan CM, Bailey ST, Bhat S. 2001. The hormone resistin links obesity to diabetes. Nature (London) 409, 307–312.
Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA. 2005. Activation of SOCS-3 by resistin. Mol Cell Biol 25, 1569-1575.
Tomaru T, Steger DJ, Lefterova ML, Schupp M, Lazar MA. 2009. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancerbinding proteins,” The Journal of Biological Chemistry 284(10), 6116–6125.
Wang C, Guan Y, Yang J. 2010. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. Int J Endocrinol. Int J Endocrinol 2010, 515136.
Eizadi Mojtaba, Bananaeifar Abdolali, Khorshidi Davood, Dooaly Hussein (2011), Human serum resistin is related to homeostasis model assessment of insulin resistance in healthy people; JBES, V1, N4, August, P55-60
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