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Hypoglycemic and antihyperglycemic effects of powder and hydro-ethanolic extract of cocoa (Theobroma cacao)

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Research Paper 16/12/2023
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Hypoglycemic and antihyperglycemic effects of powder and hydro-ethanolic extract of cocoa (Theobroma cacao)

Kouamé Estelle-Clémence, Kra Adou Koffi Mathieu, Kouassi Konan Armand Marcelin, Kouadio Kouakou John, Gnahoue Goueh
Int. J. Biosci.23( 6), 255-269, December 2023.
Certificate: IJB 2023 [Generate Certificate]
Key: Anti-hyperglycemic activityForastero cocoaHypoglycemic activity

Abstract

Cocoa is one of natural substances rich in minerals and quality metabolites. In Côte d’Ivoire, studies carried out on Forastero cocoa from the Abengourou region (Center East region) showed that this variety is richer in polyphenols than those from other Ivorian regions. This work aims to assess hypoglycemic and antihyperglycemic activities of forastero cocoa from this region of Côte d’Ivoire. Hydro-ethanolic extract (HEE) from cocoa and cocoa powder (CoPw) were administered at different doses to normoglycemic rats divided into several groups. For the glucose tolerance test, hyperglycemia was induced to normoglycemic rats by oral administration of glucose at a dose of 4 g/kg bw. Rats were orally treated with HEE, CoPw and glibenclamide before and after hyperglycemia induction. The results obtained show that HEE from cocoa has the best antioxidant activity. In addition, HEE administered at doses of 500, 800 and 1000 mg/kg bw and CoPw at a dose of 800 mg/kg bw induce hypoglycemia. This hypoglycemia is dose-dependent with the 500 and 800 mg/kg bw doses of the HEE from cocoa. Moreover, like glibenclamide (5 mg/kg bw), the doses of 800 and 1000 mg/kg bw of HEE from cocoa as well as CoPw (800 mg/kg bw) significantly reduce the hyperglycemia in post-treated and pre-treated rats. This study therefore reveals that CoPw and HEE from Forastero cocoa have good hypoglycemic and anti-hyperglycemic potential. However, HEE leads to a better activity, because it concentrates more the polyphenols, responsible for these pharmacological activities.

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