Identifying differential expression of human genes under physical, chemical and biotic stresses

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Research Paper 01/06/2021
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Identifying differential expression of human genes under physical, chemical and biotic stresses

Saba Afzal, Muhammad Younas Khan Barozai, Shafia Muzaffar, Farrukh Bashir, Farida Behlil, Uzma Jabeen, Ayesha Mushtaq, Zil-e-Huma, Bibi Sherino, Syed Shujat Ali Zaidi, Shams Riaz, Tariq Ismail
Int. J. Biosci.18( 6), 42-50, June 2021.
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Human, a well-developed multicellular organism might experience substantial health damages caused by a variety of stresses including physical, chemical and biotic. These stresses are responsible for the modification in their gene expression. Many studies on gene expression physical, chemical and biotic stresses have been conducted with the help of DNA microarray technology. The current study reported the co-shared stress-responsive genes under these stresses by utilizing the existing microarray data. Total 22283 genes were studied and 241 genes are linked to being co-shared stress-responsive. Among these stress-responsive genes, 207 were identified as up-regulated and 34 as down-regulated. All co-shared stress-responsive genes were further characterized with respect to their GO functions and chromosome number.


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