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Immunohistochemical Assessment of PTEN Expression: A Possible Tool to Screen Premalignant Endometrial Lesions

Umer Farooq, Wajiha Khalid, Saba Shamim

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Int. J. Biosci.18( 2), 186-193, February 2021

DOI: http://dx.doi.org/10.12692/ijb/18.2.186-193


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This study was carried out to observe the PTEN Expression in normal, hyperplastic and neoplastic endometrial tissues using Immunohistochemistry (IHC). In the present study, PTEN expression was assessed in 75 endometrial biopsies by using immunohistochemistry (IHC). Histopathologically, there were 15 cases of normal endometrium, 24 cases of simple hyperplasia, 22 cases of complex hyperplasia and 14 cases of endometrial carcinoma. PTEN proportionate score (PS) was +2 in all cases of the normal endometrium, +2 in 36, +1 in 6 and 0 in 4 cases of endometrial hyperplasia, +2 in 4, +1 in 4 and 0 in 4 cases of complex hyperplasia without atypia and +2 in 2, +1 in 3 and 0 in 9 cases of endometrial carcinoma. SPSS 21 was used for analyzing the data. A highly significant difference of PTEN PS (p < .001) was among these groups of endometrial lesions. It is concluded that there is a close association between loss of PTEN expression and malignant transformation. Therefore, PTEN expression assessed by immunohistochemistry (IHC) can be used as a possible tool to screen premalignant endometrial lesions.


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Immunohistochemical Assessment of PTEN Expression: A Possible Tool to Screen Premalignant Endometrial Lesions

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