Impact of a high-calorie diet on liver and kidneys in Wistar rats
Paper Details
Impact of a high-calorie diet on liver and kidneys in Wistar rats
Abstract
Obesity is a scourge of international public order and is accompanied by an impressive set of health issues, including pathologies related to the kidneys and liver. In our study, it was a question of setting up an experimental obesity model in order to evaluate the impact of the latter on the liver and kidneys of the Wistar rat. The rats were fed a high-calorie diet for 30 days. At the end of the trial, blood samples were taken for the determination of tissue lipids; the animals were then sacrificed, and their kidneys and livers were removed for histological examinations. The results revealed a significant increase in the biological markers of the liver (AST, ALT, PAL, and GGT) and those of the kidneys (uremia, uricemia, and creatinine) in the rats subjected to such a diet, thus highlighting the dysfunction of the liver and kidneys. Furthermore, histological examinations revealed no signs of damage to these organs. However, a significant increase in tissue lipids is noted. The high-calorie diet, therefore, caused an accumulation of fat in the liver and kidneys of the rats. This accumulation could reflect the onset of hepatic steatosis (fatty liver disease) in rats.
Angulo P, Hui JM. 2007. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 45(4), 846-54. https://doi.org/10.1002/hep.21496
Arici Mustafa, Ravinder Chana, Andrew Lewington Jez Brown, Nigel John Brunskill. 2003. Stimulation of Proximal Tubular Cell Apoptosis by Albumin Bound Fatty Acids Mediated by Peroxisome Proliferator Activated Receptor-Gamma. Journal of the American Society of Nephrology: JASN 14(1), 17‑27. https://doi.org/10.1097/01.asn.0000042167.66685.ea
Bragança AdS, Tran TN. 2017. Increased liver tests. Département de médecine communautaire, de Premier recours et des urgences.3. https://www.hug.ch/sites/interhug/files/structures/medecine_de_premier_recours/Strategies/strategie_tests_hepatiques.pdf
Coco B, Oliveri F, Maina AM. 2007. Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases. Journal of Viral Hepat 14, 360- 369. https://doi.org/10.1111/j.1365-2893.2006.00811.x
Cole TJ, Lobstein T. 2012. International Extended Body Mass Index (IOTF) thresholds for thinness, overweight and obesity https://doi.org/10.1111/j.2047-6310.2012.00064.x
Darimont Yurini M, Epitaux M, Zbinden I, Richelle R, Montell E, Martinez AF, Mace K. 2004.β3-adrenoceptor agonist prevents alterations of muscle diacylglycerol and adipose tissue phospholipids induced by a cafeteria diet. Nutrition Metabolism 1, 4-12. https://doi.org/10.1186%2F1743-7075-1-4
Daum G. 1985. “Lipids of mitochondria.” Biochim Biophys Acta 822(1), 1-42.
Recknagel RO, Glende Jr EA, Dolak JA, Waller RL. 1989. Mechanisms of carbon tetrachloride toxicity. Pharmacology and Therapeutics 43, 139-154. https://pubmed.ncbi.nlm.nih.gov/2408671/#:~:text=PMID%20%3A%202408671,DOI%C2%A0%3A%2010.1016/0304%2D4157(85)90002%2D4,-Aucun%20r%C3%A9sum%C3%A9%20disponible
Folch J, Lees M, Sloane Stanley GH. 1957. A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues. The Journal of Biological Chemistry 226(1), 497‑509. https://doi.org/10.1083/jcb.1.2.173
Hamlat N, Neggazi S, Benazzoug Y, Kacimi G, Chaïb S, Aouichat B, Bouguerra S. 2008. Régime hyperlipidique et processus artérioscléreux chez Rattus norvegicus. Sciences et Technologie 27, 49-56. https://dx.doi.org/10.4314/ijbcs.v11i6.31
Kamijo Yuji, Yoko Kaneko, Toru Ichikawa, Nobuhiko Kobayashi, Takayuki Koyama, Tetsuji Kakegawa, Hiroshi Kamijo. 2002. A Case of Nephrotic Syndrome Due to Lupus Nephritis Which Was Controlled with Low-Density Lipoprotein Apheresis . Therapeutic Apheresis: Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis 6(6), 459‑ 62. https://doi.org/10.1046/j.1526-0968.2002.00458.x
Kent PS. 2014 Academy of Nutrition and Dietetics and National Kidney Foundation: revised 2014 Standards of Practice and Standards of Professional Performance for registered dietitian nutritionists (competent, proficient, and expert) in nephrology nutrition. J Ren Nutr 24(5), 275-285 e45 p. https://doi.org/10.1053/j.jrn.2014.05.008
Lafontan M. 2013. Fat mass expansion, fatty acids and adipokines: metabolic markers and risk factors for cardiovascular pathologies. Annals of Pharmacotherap. 71(1), 13-26. https://doi.org/10.1016/j.pharma.2012.07.008
Lichtenstein AH, Kenned E, Barrier P. 1998. Dietary fatty consumption and health https://doi.org/10.1111/j.1753-4887.1998.tb01728.x
Martinez SM, Foucher J, Combis JM. 2012. Longitudinal liver stiffness assessment in patients with chronic hepatitis C undergoing antiviral therapy. PLoS One 7, e47715. https://doi.org/10.1371/journal.pone.0047715
Milagro FI, Campion J, Martinez JA. 2006. Weight gain induced by high-fat feeding involves increased liver oxidative stress. Obesity (Silver Spring). 14(7), 1118- 1123. https://doi.org/10.1038/oby.2006.128
Nordoy A. 2001, polyunsaturated fatty acids and cardiovascular diseases. Lipids 36, 127-129. https://doi.org/10.1007/s11745-001-0695-7
Okeke N, Emeka A, Johntel C. 2014. Biochemical Taurine alleviated modification in male Wistar rats co-exposed to chlorpyrifos and lead. International Journal of Environmental Science and Toxicology. 2(9), 104-115. https://www.semanticscholar.org/paper/Biochemical-Taurine-alleviated-modification-in-male-Okeke-Emeka/05bdd5baff26919aee830961d028d2067ddd74e8
OMS. 2002. Organisation Mondiale de la Santé. Rapport sur la santé dans le monde. Réduire les risques et promouvoir une vie saine. Organisation Mondiale de la Santé, 4 p. https://apps.who.int/iris/handle/10665/42522
Organisation Mondiale de la Santé. 2008. Obésité : prévention et prise en charge de l‘épidémie mondiale. Rapport sur la santé dans le monde. Genève https://apps.who.int/iris/handle/10665/42734
OMS. 2011. Organisation Mondiale de la Santé. Rapport sur la situation mondiale des maladies non transmissibles. Genève. 20C p. http://apps.who.int/iris/bitstream/handle/10665/149294/WHO_NMH_NVI_15.1_fre.pdf
Pan A, Yu D, Demark W, Franco O, Lin X. 2009. Metaanalysis of the effects of flaxseed interventions on blood lipids. The American Journal of Clinical Nutrition 90, 288-297. https://doi.org/10.1007/s11690-009-0196-y
Postic C, Girard J. 2008. The Role of the Lipogenic Pathway in the Development of Hepatic Steatosis. Diabetes & Metabolism 34 (6 Pt 2), 643‑ 48. https://doi.org/10.1016/S1262-3636(08)74599-3.
Ray S, Chakrabarti P. 1999. Altered Lipid Peroxidation and Antioxidant Potential in Human Uterine Tumors. Indian Journal of Experimental Biology 37(5), 439‑ 43. https://pubmed.ncbi.nlm.nih.gov/?term=Ray+S&cauthor_id=10492614
Saltiel AR. 2000. Series Introduction: The Molecular and Physiological Basis of Insulin Resistance: Emerging Implications for Metabolic and Cardiovascular Diseases. The Journal of Clinical Investigation 106(2), 163‑64. https://doi.org/10.1172/JCI10533.
Saxena G, Flora SJ. 2004. Lead-induced oxidative stress and hemato-logical alterations and their response to combined administra-tion of calcium disodium EDTA with a thiol chelator in rats.J Biochem Mol Toxicol 18(4), 221-233. https://dergipark.org.tr/en/download/article-file/860539
Senou M, Khalifa C, Thimmesch M, Jouret F, Devuyst O, Col V, Gérard AC. 2010. A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid. The Journal of Clinical Endocrinology and Metabolism 95(8), 4021-30. https://doi.org/10.1210/jc.2010-0228
Steinmetz KA, Potter JD. 1996. Vegetables, fruit, and cancer prevention: a review. Journal of the American Dietetic Association 96(10), 1027–1039. https://doi.org/10.1016/s0002-8223(96)00273-8
Shulman, Stanford T. 2006. Obesity: A Real Epidemic. Pediatric Annals 35(11), 773‑ 74 https://doi.org/10.3928/0090-4481-20061101-01
Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, Xu Q, Qian ZM. 2006. Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. Journal. Nutr. Biochem. 17, 177–182. https://doi.org/10.1016/j.jnutbio.2005.06.008
Thomas Ravi, Rajul Parikh, Ronnie George, Rajesh S. Kumar, Jayaprakash Muliyil. 2003. Five-Year Risk of Progression of Ocular Hypertension to Primary Open Angle Glaucoma. A Population-Based Study. Indian Journal of Ophthalmology 51(4), 329‑33. https://www.ijo.in/searchresult.asp?search=&author=R+Thomas&journal=Y&but_search=Search&entries=10&pg=1&s=0
Vergniol J, Foucher J, Terrebonne E. 2011. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology 140, 1970-1979. https://doi.org/10.1053/j.gastro.2011.02.058
Vial G, Dubouchaud D, Couturier K, Taleux N, Athias A, Galinier A, Casteilla L, Leverve X. 2009. Effect of high-fat diet on energy metabolism and ROS production in rat liver. Soumis à Hepatology https://doi.org/10.1016/j.jhep.2010.06.044
Wang Xiao-Chun, Chang-Hao Sun, Xiao-Hong Zhang, Li-Jun Zhao, Jing Zheng. 2005. [Effects of early weaning on the blood glucose, blood lipid and hormone of rat fed a high fat diet].Wei Sheng Yan Jiu = Journal of Hygiene Research 34(3), 331‑33. https://pubmed.ncbi.nlm.nih.gov/?term=Wang+XC&cauthor_id=16111044
Wennberg Richard, Camilla Zimmermann. 2006. Progress: Measuring the Benefit. Re: The Numbers Needed to Treat for Neurological Disorders. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 33(2), 254; author reply 254. https://doi.org/10.1017/s031716710000442x
West DB, York B. 1998. Dietary Fat, Genetic Predisposition, and Obesity: Lessons from Animal Models. The American Journal of Clinical Nutrition 67(3), 505S‑ 512S. https://doi.org/10.1093/ajcn/67.3.505s
Yki-Järvinen H, Westerbacka J. 2005. The Fatty Liver and Insulin Resistance. Current Molecular Medicine 5(3), 287‑95. https://doi.org/10.2174/1566524053766031
Ziegler O. 2009. Faut-il démédicaliser le traitement de l’obésité ? Obésité 4, 87-88. https://doi.org/10.1007/s11690-009-0196-y
Zimmet P, Alberti KG, Shaw J. 2001. Global and societal implications of the diabetes epidemic. Nature 414(6865), 782-7. https://doi.org/10.1038/414782a
Chokki Steven J.A.P.T.V, Tchogou Atchadé Pascal, Behanzin Gbèssohèlè Justin, Senou Maximin, Ahokpe A. Mélanie, Sezan Alphonse (2023), Impact of a high-calorie diet on liver and kidneys in Wistar rats; IJB, V23, N2, August, P27-37
https://innspub.net/impact-of-a-high-calorie-diet-on-liver-and-kidneys-in-wistar-rats/
Copyright © 2023
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0