Welcome to International Network for Natural Sciences | INNSpub

Paper Details

Research Paper | February 1, 2014

VIEWS 1
| Download 1

Impact of chronic exercise training on pro-inflammatory cytokine interleukine-6 in adult men with asthma

Ali Jalalvand, Masoud Moeini, Javad Almasi, Naser Farokhroo

Key Words:


J. Bio. Env. Sci.4(2), 358-363, February 2014

Certification:

JBES 2014 [Generate Certificate]

Abstract

Evidence supports an important contribution of low-grade systemic inflammation in asthma or chronic obstructive pulmonary disease. The objective of present study was to determine whether aerobic training program affect serum IL-6 in males with asthma. For this purpose, fasting blood samples were collected before and at the end of aerobic training (3 months/3 days weekly) in order to measuring serum interleukin-6 in twenty two adult men with chronic asthma that randomly divided into exercise or control groups. Anthropometrical markers were also measured before and after exercise program in two groups. Independent student T test was used for between group’s comparison at baseline and paired T test used for determine significant changes in variables by exercise intervention. Exercise program decreases body weight, body mass index and body fat percentage compared to baseline. There were no significant differences for serum IL-6 [pre, 5.33(3.6); post, 5.65(2.71) pg/ml (p = 0.76)]. These data suggest that long term aerobic training is not associated with an anti-inflammatory property in asthma patients. Further studies are necessary to elucidate the significance of this exercise program on other inflammatory cytokines.

VIEWS 1

Copyright © 2014
By Authors and International Network for
Natural Sciences (INNSPUB)
http://innspub.net
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Impact of chronic exercise training on pro-inflammatory cytokine interleukine-6 in adult men with asthma

Agrawal A, Rengarajan S, Adler KB, Ram A, Ghosh B, Fahim M, Dickey BF. 2007. Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma. Journal of Applied Physiology 102, 399– 405.

Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. 2000. Asthma from bronchoconstriction to airways inflammation and remodeling. American Journal of Respiratory and Critical Care Medicine 161, 1720–1745.

Bradding PJA, Roberts KM, Britten S, Montefort R, Djukanovic R, Muller CH. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. American Journal of Respiratory Cell and Molecular Biology 10, 471–480.

Broide DHM, Lotz AJ, Cuomo DA, Coburn EC, Federman I. Wasserman. 1992. Cytokines in symptomatic asthma airways. Journal of Allergy and Clinical Immunology 89, 958–967.

Castro-Rodríguez JA. 2007. Relationship between obesity and asthma. Archivos de Bronconeumología 43(3), 171-5.

De Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Bellioo D, Conde R. 2007. Effects of a low-fat versus a low-carbohydrate diet on adipocytokines in obese adults. Hormone Research 67(6), 296-300.

Deetz DC, Jagielo PJ, Quinn TJ, Thorne PS, Bleuer SA, Schwartz DA. 1997. The kinetics of grain dust–induced inflammation of the lower respiratory tract. American Journal of Respiratory and Critical Care Medicine 155, 254-259.

Doganci AT, Eigenbrod N, Krug GT, De Sanctis M, Hausding VJ, Erpenbeck B, Haddad HA. 2005. The IL-6R chain controls lung Treg development and function during allergic airway inflammation in vivo. Journal of Clinical Investigation 115, 313–325.

Gosset PA, Tsicopoulos B, Wallaert C, Vannimenus M, Joseph AB, Tonnel A. 1991. Increased secretion of tumor necrosis factor and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. Journal of Allergy and Clinical Immunology 88, 561– 571.

Hamid QJ, Barkans Q, Meng S, Ying JS, Abrams AB. 1992. Human eosinophils synthesize and secrete interleukin-6, in vitro. Blood 3, 1496– 1501.

Jung SH, Park HS, Kim KS, Choi WH, Ahn CW, Kim BT. 2008. Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. Journal of Nutritional Biochemistry 19(6), 371-5.

Marini ME, Vittori J, Hollemborg S. 1992. Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony- stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. Journal of Allergy and Clinical Immunology 89, 1001–1009.

Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C. 2003. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research 11(9), 1048-54.

Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M. 2005. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 54(11), 1472-9.

Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA. 2009. IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens. Journal of Immunology 183(3), 1732-8.

Qiu ZM, Fujimura K, Kurashima S, Nakao N. 2004. Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen. Clinical & Experimental Allergy 34, 1321–1328.

Rogers DF. 2004. Airway mucus hypersecretion in asthma: an undervalued pathology? Current Opinion in Pharmacology 4, 241–250.

Settin A, Zedan M, Farag M, Ezz El, Regal M, Osman E. 2008. Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children. Indian Journal of Pediatrics 75(10), 1019-23.

Wang JRJ, Homer Q, Chen JA. 2000. Endogenous and exogenous IL-6 inhibit aeroallergen-induced Th2. inflammation. Journal of Immunology 165, 4051–4061.

Wu SJ, Chen P, Jiang XN, Liu ZJ. 2005. C-reactive protein level and the correlation between lung function and CRP levels in patients with chronic obstructive pulmonary diseases. Zhong nan da xue xue bao. Yi xue ban 30(4), 444-6.

Yokoyama A, Kohno N, Fujino S, Hamada H, Inoue y, Fujioka S, Ishida S, Hiwada K. 1995. Circulating interleukin-6 levels in patients with bronchial asthma. American Journal of Respiratory and Critical Care Medicine 151, 1354–1358.

Yokoyama A, Kohno N, Sakai K, Kondo K, Hirasawa Y, Hiwada K. 1997. Circulating Levels of Soluble Interleukin-6 Receptor in Patients with Bronchial Asthma. American Journal of Respiratory and Critical Care Medicine 156(5), 1688-91.

Yudkin JS, Stehouwer CD, Emeis JJ. 1999. C reactive protein in healthy subjects: associations with obesity, insulin resistance and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thrombosis Vascular Biology 19, 972-8.

Zureik M, Benetos A, Neukirch C. 2001. Reduced pulmonary function is associated with central arterial stiffness in men. American Journal of Respiratory and Critical Care Medicine 164, 2181-5.

SUBMIT MANUSCRIPT

Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background