Impact of chronic organic Mitral Regurgitation on Right Ventricular Diastolic Function using Doppler echocardiographic study in multi cardiac center in Baghdad

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Research Paper 01/10/2018
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Impact of chronic organic Mitral Regurgitation on Right Ventricular Diastolic Function using Doppler echocardiographic study in multi cardiac center in Baghdad

Attaa K. Taha, Ghazi F. Al-haji, Ghassan Thabet Saeed
Int. J. Biosci.13( 4), 92-101, October 2018.
Certificate: IJB 2018 [Generate Certificate]


To study the effect of left ventricular volume overload on right ventricular diastolic function by Doppler echocardiography in patients with chronic organic compensated mitral regurgitation. A cross-sectional study held in multi cardiac center in Baghdad from April 2015 to June 2016. Patients categorized in to two groups; Thirty-one were without pulmonary hypertension (group I, mean age 32±7.1 years) and thirty of patients were with pulmonary hypertension (group II, mean age 36.1±5.7years). All of them compared with sixty-one healthy individuals serving as a control group (group III, mean age 32.1±6.6 years). Transthoracic echocardiography (multiple views) M-mode, Two-dimensional and Doppler were done for all groups of study. Conventional and tissue Doppler echocardiographic assessment of right ventricular diastolic function revealed impairment in up to 44.3% of patients, (19.4% in group I vs 70% in group II, P<0.001). Patients had lower right ventricular E-wave velocity, lower E/A ratio, and prolonged right ventricular isovolumic relaxation time compared to control. Tissue Doppler analysis showed lower E’, and lower E’/A’ ratio. All changes were statistically significant at P < 0.001. Patients with pulmonary hypertension were older with higher E/E’ ratio in comparison to the other two groups (5.79±1.75 in group II vs 3.91±0.41, 4.08±0.93 in group III and I, respectively, P <0.001). Right ventricular diastolic function is frequently impaired in patients with chronic organic compensated mitral regurgitation. Early identification of such changes by Doppler echocardiography might help in identifying patients who need more aggressive therapy early on in the disease process.


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