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Impact of infertility activity of eugenol and Ocimum sanctum Linn. leaf extract on Antioxidant Enzymes study in female albino rats

Research Paper | December 1, 2020

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Venkataramanaiah P, Madduru Renuka, Yenukolu Aparna, Chakali Babu, Vasuru Kesavulu, Motireddy Srinivasulu Reddy

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Int. J. Biosci.17( 6), 373-386, December 2020

DOI: http://dx.doi.org/10.12692/ijb/17.6.373-386


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The present study is aimed to evaluate the antifertility activity of the effect of Eugenol and Ocimum sanctum Linn. Leaf extract on Antioxidant Enzymes and Histological study (Reproductive and non-reproductive Organs). Experiments were conducted to investigate the healthy female albino rats were administered with EUG (99% pure) at a dose of 0.4 ml/day/rat and OS Linn. (Tulsi) leaf extract at a dose of 500 mg/kg body weight/day/rat orally for 15 days. One-way ANOVA analysis with Dunnett’s multiple comparison test is used for analyzing data. The in vivo results demonstrated that the Catalase (CAT) and Superoxide dismutase (SOD) were significantly increased in all tissues by both administrations (P<0.001). The results represented in the GRx, GSH, GST and NO activity levels were significantly increased in all tissues by both administrations (P<0.001). The results represented in the LPO, Vitamin-E, Vitamin-C and Vitamin-A Levels were significantly reduced in all tissues by both administrations (P<0.001). The results of the present investigation suggest that The ovarian significantly increases in catalase activities suggest a degenerative changes in the ovary which includes a reduction in number of ovarian follicles and atrophic changes in the oocyte and granulosa cells. For instance, during folliculogenesis, GST protects the oocytes from oxidative damage. The suggests a reduction of its defence activity against cellular oxidative damage in the reproductive tissues. Accentuates the potential benefits of the female reproductive system of rats. Vitamin C possesses some functions such as collagen synthesis increment, impact on sexual hormone production, and protection of sexual cells against free radicals associated with infertility.


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Impact of infertility activity of eugenol and Ocimum sanctum Linn. leaf extract on Antioxidant Enzymes study in female albino rats

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