Impact of maternal exposure to e-cigarette vapor on offspring health outcomes: A systematic review of animal studies
Paper Details
Impact of maternal exposure to e-cigarette vapor on offspring health outcomes: A systematic review of animal studies
Abstract
Since their introduction in 2007, electronic cigarettes have gained popularity, much of which come from the notion that it is a safe alternative to traditional cigarettes, even for women during pregnancy. These assertions are based in large part on the fact that e-cigarette vapors contain less toxicant compared with cigarette smoke. Little is known yet about the effects of prenatal exposure on offspring; hence, this paper aims to provide an overview of the current research on the impacts of prenatal e-cigarette exposure to offspring health outcomes. Since a clinical study in humans is scarce, this review refers only to animal studies published from 2018 to present. All relevant studies were systematically selected from online databases (Google Scholar, Web of Science, PubMed, NCBI, Research Gate, Science Direct). The search yielded 10 significant research papers. Most studies included made use of murine model for maternal e-cigarette exposure. Prenatal exposure to e-cigarettes of high nicotine levels resulted to reduced birth weight and litter size. Maternal vaping produced developmental dysfunction in cardiovascular, pulmonary, hepatic and renal systems of offspring. Moreover, afflicted offspring had short term memory deficits, and impaired learning and object recognition ability. Hyperactivity and decreased anxiety behavior are also exhibited by prenatally exposed offspring. It is also noted that e – cigarette vapor confers adverse health outcomes, independent of nicotine content. Based on these findings, it is then recommended that a more intense education and awareness program on the detrimental effects of e-cigarette smoking be given to pregnant women of child-bearing age, as well as prenatal care professionals.
Aboaziza E, Feaster K, Hare L, Chantler PD, Olfert IM. 2023. Maternal electronic cigarette use during pregnancy affects long-term arterial function in offspring. Journal of Applied Physiology 134(1), 59-71.
Archie SR, Sifat AE, Zhang Y, Villalba H, Sharma S, Nozohouri S, Abbruscato TJ. 2023. Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age. Fluids and Barriers of the CNS 20(1), 1-17.
Burrage EN, Aboaziza E, Hare L, Reppert S, Moore J, Goldsmith WT, Olfert IM. 2021. Long-term cerebrovascular dysfunction in the offspring from maternal electronic cigarette use during pregnancy. American Journal of Physiology-Heart and Circulatory Physiology 321(2), H339-H352.
Chen H, Li G, Chan YL, Chapman DG, Sukjamnong S, Nguyen T, Oliver BG. 2018. Maternal e-cigarette exposure in mice alters DNA methylation and lung cytokine expression in offspring. American Journal of Respiratory Cell and Molecular Biology 58(3), 366-377.
Li G, Chan YL, Nguyen LT, Mak C, Zaky A, Anwer AG, Saad S. Page Impact of maternal e-cigarette vapour exposure on renal health in the offspring.
Li G, Chan YL, Wang B, Saad S, George J, Oliver BG, Chen H. 2020. E‐cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring. Annals of the New York Academy of Sciences 1475(1), 64-77.
Li G, Chan YL, Wang B, Saad S, Oliver BG, Chen H. 2020. Replacing smoking with vaping during pregnancy: impacts on metabolic health in mice. Reproductive Toxicology 96, 293-299.
Nguyen T, Li GE, Chen H, Cranfield CG, McGrath KC, Gorrie CA. 2018. Maternal e-cigarette exposure results in cognitive and epigenetic alterations in offspring in a mouse model. Chemical Research in Toxicology 31(7), 601-611.
Wang Q, Sundar IK, Blum JL, Ratner JR, Lucas JH, Chuang TD, Rahman I. 2020. Prenatal exposure to electronic-cigarette aerosols leads to sex-dependent pulmonary extracellular-matrix remodeling and myogenesis in offspring mice. American Journal of Respiratory Cell and Molecular Biology 63(6), 794-805.
Wetendorf M, Randall LT, Lemma MT, Hurr SH, Pawlak JB, Tarran R, Caron KM. 2019. E-cigarette exposure delays implantation and causes reduced weight gain in female offspring exposed in utero. Journal of the Endocrine Society 3(10), 1907-1916.
Zarina Kate C. Laggui, 2023. Impact of maternal exposure to e-cigarette vapor on offspring health outcomes: A systematic review of animal studies. J. Biodiv. Environ. Sci., 23(1), 163-174.
Copyright © 2023 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.