home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Implication of insertion/deletion polymorphism of angiotensin converting enzyme gene in the occurrence of type 2 diabetes in the Gabonese Population

Paper Details

Research Paper 01/12/2017
Views (319) Download (16)
current_issue_feature_image
publication_file

Implication of insertion/deletion polymorphism of angiotensin converting enzyme gene in the occurrence of type 2 diabetes in the Gabonese Population

Ndong Atome Guy Roger, Ovono Abessolo Felix, Mbang Bengone Aude Synthia, Ollomo Benjamin, Yacka Laurianne, Lebibi Jacques, Ngou-Milama Edouard
Int. J. Biosci.11( 6), 61-67, December 2017.
Certificate: IJB 2017 [Generate Certificate]
Key: Angiotensin converting enzyme geneInsertion/Deletion polymorphismType 2 diabetes

Abstract

Diabetes is a metabolic disease most often associated with complications when the biological parameters are uncontrolled, so management of diabetes remains a challenge in Africa. The aim of this study was to find a relationship between the I/D polymorphism of the gene encoding for angiotensin converting enzyme (ACE) and type 2 diabetes in Gabonese subjects. This study was carried out in the laboratory of the Research Unit of the University of Health Sciences. The study population consisted of 225 subjects. This panel was composed of 88 controls (normoglycemic and non-hypertensive and not having a family history of diabetes) and 137 type 2 diabetic individuals. The genotypic analysis of the ACE gene of the different subjects was carried out by the technique of Polymerase Chain Reaction (PCR). Categorical and continuous variables were compared between diabetic patients and controls using the Chi-square test (χ²) for categorical and the ANOVA test for continuous. The distribution of DD, ID, and II genotypes in controls and diabetics was 63.6%, 33%; 3.4% respectively and 65.7%; 31.4%; 2.9%. In addition, the allelic distribution showed that the alleles I and D in the controls and the diabetic subjects had proportions of 19.9%; 80.1% vs. 18.6%; 81.4% respectively. The genotypic and allelic differences between the two groups were not significant (p ≥ 0.05). Therefore the allele D would not be the factor involving the I/D polymorphism in the occurrence of type 2 diabetes in the Gabonese population.

VIEWS 13
Cover PDF

Alsafar H, Hassoun A, Almazrouei S, Kamal W, Almaini M, Odama U, Rais N. 2015. Association of Angiotensin Converting Enzyme Insertion Deletion Polymorphism with Hypertension in Emiratis with Type 2 Diabetes Mellitus and Its Interaction with Obesity Status. Disease Markers Article ID 536041, 7.

Arfa I, Abid A, Nouira S, Elloumi-Zghal H, Malouche D, Mannai I, Zorgati MM, Ben Alaya N, Rebai A, Zouari B, Ben Ammar S, Ben Rayana MC, Hmida S, Blousa-Chabchoub S, Abdelhak S. 2008. Lack of association between the angiotensin-converting enzyme gene (I/D) polymorphism and diabetic nephropathy in Tunisian type 2 diabetic patients. Journal of the Renin Angiotensin-Aldosterone system 9, 32-36.

Baroudi T, Bouhaha R, Moran-Moguel C, Sanchez-Corona J, Ben Maiz H, Kammoun Abid H, Benammar-Elgaaied A. 2009. Association of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene with type 2 diabetes in two ethnic groups of Jerba Island in Tunisia. Journal of the renin Angiotensin Aldosterone System 10, 35-40.

Chmaisse HN, Jammal M, Fakhoury H, Fakhoury R. 2009. A study on the association between angiotensin-I converting enzyme I/D dismorphism and type 2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation 20(6), 1038-46.

D’Ivernois J, Gagnayre R. 2011. Compétences d’adaptation à la maladie du patient: une proposition. Education, Thérapeutique du Patient 3(2), 201- 5.

Farmer Y, Avard D. 2008. La composante du diabète de type 2: Suivi des progrès scientifiques du projet DGDG. Diabetes voice; 53, 31-33.

Fédération Internationale du Diabète. 2015. Atlas du diabète de la FID. Bruxelles, Belgique, 7e édition.

Feng Y, Niu T, Xu X, Chen C, Li Q, Qian R, Wang G, Xu X. 2002. Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes. Diabetes 51, 1986-8.

Garg M, Angus PW, Burrell LM, Herath C, Gibson PR, Lubel JS. 2012. Review article: the pathophysiological roles of the renin-angiotensin system in the gastro intestinal tractus. Alimentary pharmacology and therapeutics 35, 414-28.

Graham H. 2003. Comprendre le diabète: la génétique. Diabetes Voice; 48, 32-5.

Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T. 2007. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 50, 2461–2466

Jones E, Vinh A. 2008. AT2 receptors: Functional relevance in cardiovascular disease. Pharmacology & therapeutics 120(3), 292-316.

Marre M, Bernadet P, Gallois Y, Savagner F, Guyene TT, Hallab M, Cambien F, Passa P, Alhenc-Gelas F. 1994. Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels and diabetic retinal and renal complications. Diabetes 43, 54-8.

Parchwani DN, Palandurkar KM, Hema Chandan Kumar D, Patel DJ. 2015. Genetic predisposition to diabetic nephropathy: evidence for a role of ACE (I/D) gene polymorphism in type 2 diabetic population from Kutch region. India Journal Clinical Biochemistry 30(1), 43-54.

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. 1990. An insertion/deletion polymorphism in the angiotensin converting enzyme gene accounting for the half the variance of serum levels. Journal Clinical Investigation; 86, 1343-6.

Sasaki S, Inoguchi T. 2012. The role of oxidative stress in the pathogenesis of diabetcs vascular complications. Diabetes and metabolism journal 36, 255-61.

Scheen A, Paquot N. 2012. Le diabète de type 2: voyage au cœur d’une maladie complexe. Revue Médicale Liège 67, 326- 31.

Sung-Kyu Ha. 2014. Ace insertion/deletion polymorphism and diabetic nephropahy: clinical implications of genetic information. Journal of diabetes research Article ID 846068, 8.

Van Vliet-Ostaptchouk JV, Onland-Moret NC, Van Haeften TW, Franke L, Elbers CC, Shiri-Sverdlov R, Van der Schouw YT, Hofker MH, Wijmenga C. 2008. HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. European Journal of Human Genetics: EJHG; Leiden16(5), 652-6.

Yasushi F, Takeshi S, Hiroto F, Shohei M,  Akiko K, Asako D, Masahiro N, Hideyuki S, Tokio S, Kishio N. 2008. Polymorphisms in the IDE–KIF11–HHEX Gene Locus Are Reproducibly Associated with Type 2 Diabetes in a Japanese Population. J Clin Endocrinol Metab 93(1), 310-314.

Zhou YF, Hui Yan, Xiao-Ping Hou, Jing-Li Miao, Jing Zhang, Qiao-Xiang Yin, Jun-Jie Li, Xiao-Yan Zhang, Yuan-Yuan Li, Hui-Lan Luo. 2013. Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels. Lipids in Health and Disease; 12, 187-91.

Submit Manuscript