In silico anticancer targets of L-menthol
Paper Details
In silico anticancer targets of L-menthol
Abstract
Menthol is a cyclic monoterpene which is used as flouring and therapeutic agent. It has antibacterial, antifungal, and anticancer properties. Many reports confirmed its activity as anticancer molecule. The present work was design to prove its anticancer property in-vitro as well. Docking of L-menthol with different cancer protein was carried out to confirm its mode of action on cancer cells. The results are very promising and they directly indicating that the menthol is targeting the proteins which play major role in cancer progression.
Balunas MJ, Kinghorn AD. 2005. Drug discovery from medicinal plants. Life sciences 78(5), 431-441. https://doi.org/10.1016/j.lfs.2005.09.012
Barret JM, Etievant C, Baudouin C, Skov K, Charveron M, Hill BT. 2002. F 11782, a novel catalytic inhibitor of topoisomerases I and II, induces atypical, yet cytotoxic DNA double-structure. Anticancer research 22(1A), 187-92.
Berman HM. 2008. The Protein Data Bank: a historical perspective. Acta Crystal Section A: Foundations of Crystallography 64(1), 88-95. https://doi.org/10.1107/S0108767307035623
Bromm B, Scharein E, Darsow U, Ring J. 1995. Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neuroscience Letters. 187, 157–160. https://doi.org/10.1016/0304-3940(95)11362-z
Chang Jang-Yang, Hsieh Hsing-Pang, Pan Wen-Yu. 2003. Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent. Biochemical Pharmacology 65, 2009–2019. https://doi.org/10.1016/s0006-2952(03)00197-7
Faridi U, Sisodia BS, Shukla AK, Shukla RK, Darokar MP, Dwivedi UN, Shasany AK. 2011. Proteomics indicates modulation of tubulin polymerization by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation. Proteomics 11, 1–5. https://doi.org/10.1002/pmic.201000691
Hageway P, Searls David B. 2011. The roots of Bioinformatics in theoretical biology. Computational Biology 7(3), 73-5.
Inohara N, Gourley TS, Carrio R. 1998. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. The Journal of Biological Chemistry 273, 32479–32486. https://doi.org/10.1074/jbc.273.49.32479
Jing-Pin L, Hsu-Feng L, Jau-Hong L, Jaung-Gung L, Te-Chun H, Lii-Tzu W, Jing-Gung C. 2005. (-)-Menthol Inhibits DNA Topoisomerases I, II· and ‚ and Promotes NF-Î B expression in Human Gastric Cancer SNU-5 Cell. Anticancer Research 25, 2069-2074.
Jordan A, Hadfield JA, Lawrence NJ, McGown AT. 1998. Tubulin as a Target for Anticancer Drugs: Agents Which Interact with the Mitotic Spindle: Medicinal Research Reviews 18(4), 259–296,
Kamatou Guy PP, Vermaak Ilze, Viljoen Alvaro M, Lawrence Brian M. 2013. Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry 96, 15-25. https://doi.org/10.1016/j.phytochem.2013.08.005
Kazemi BA, Karmi SM, kabiri HR, Tavakoli K. 2013. Docking Studies of Competitive Interaction of Human Serum Albumin with Ibuprofen and aspirin using Hex Docking Software. Journal of Emerging Trends in Computing and Information Sciences 4(1), 97-9.
Leroy FL, Shyamal DD, Tsai-Kunl, Yong Mao, Mei Sun, Sai-Peng S. 2006. Mechanism of Action of Camptothecin. Annals of the New York Academy of Sciences 922(1). https://doi.org/10.1111/j.1749-6632.2000.tb07020.x
Li Z, Wan H, Shi Y, Ouyang P. 2004. Personal Experience with Four Kinds of Chemical Structure Drawing Software: Review on ChemDraw, ChemWindow, ISIS/Draw, and ChemSketch. Journal of chemical information and computer sciences. . 44(5), 1886–1890.
McIlwain DR, Berger T, Mak TW. 2013. Caspase Functions in Cell Death and Disease. Cold Spring Harbor Perspectives in Biology 5, 008656 https://doi.org/10.1101/cshperspect.a008656
Nair B. 2001. Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. International journal of Toxicology 20(3), 61-73.
Parker AL, Kavallaris M, McCarroll JA. 2014.Microtubules and Their Role in Cellular Stress in Cancer. Frontiers in Oncology 4, 153. https://doi.org/10.3389/fonc.2014.00153
Sobral MV, Xavier AL, Lima TC, de Sousa DP. 2014. Antitumor Activity of Monoterpenes Found in Essential Oils. The Scientific World Journal 35.
Tadashi U, Hiroyuki O, Yasuhisa A, Kazuhiko M, Kazuhiro S, Mitsuhiro Y. 2016. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe Cell. 164(3), 327-580. https://doi.org/10.1155/2014/953451
Vishnuvarthan VJ, Lakshmi KS, Srividya AR. 2017. In-Silico Screening of Flavonoids Targeted for Death Receptors in Cancer by Using Hex Molecular Docking. Journal of Young Pharmacists 9(2), 168. https://doi.org/10.5530/jyp.2017.9.33
Wang Y, Xiao J, Suzek, TO, Zhang J, Wang J, Bryant SH. 2009. PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic acids research 37(2), 623-633. https://doi.org/10.1093/nar/gkp456
Ware CF. 2008. The TNF superfamily-2008. Cytokine Growth Factor Review 19, 183–186. https://doi.org/10.1016/j.cytogfr.2008.05.001
Wishart DS, Knox C, Guo AC. 2006. Drug Bank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Research 34, 668-72. https://doi.org/10.1093/nar/gkj067 https://www.rcsb.org/pdb/
Youle RJ, Strasser A. 2008. The BCL-2 protein family: Opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology 9, 47–59. https://doi.org/10.1038/nrm2308
Yukata O, Yuri M, Takehiro S. 2013. Highly Precise Protein-Protein Interaction Prediction Based on Consensus between Template Based and de novo Docking Methods. BMC Proceedings 7(7), 1-10. https://doi.org/10.1186/1753-6561-7-S7-S6
Yu SE, Park SH, Jang YK. 2010. Epigenetic silencing of TNFSF7 (CD70) by DNA methylation during progression to breast cancer. Molecules and Cells 29, 217–221. https://doi.org/10.1007/s10059-010-0052-9
Uzma Faridi, Fahad Al-Mutairi , 2019. In silico anticancer targets of L-menthol. Int. J. Biosci., 15(4), 248-253.
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