Int. J. Biosci.21(2), 279-286, August 2022
Increasing inflammation-mediated health issues have driven the search for more natural anti-inflammatory drug sources. In this study, the anti-inflammatory activity of Nephrolepis biserrata rhizome and Angiopteris palmiformis frond extracts were determined via inhibition of pro-inflammatory enzymes, 15-lipoxygenase (15-LOX) and cyclooxygenase-2 (COX-2). Extraction with absolute ethanol was done followed by subsequent partitioning with hexane, ethyl acetate, and water. Results revealed that the ethyl acetate-soluble partition (Nb-EtOAc) and aqueous partition (Nb-Aq) of N. biserrata and the ethanolic extract (Ap-EtOH) of A. palmiformis exhibit active inhibition against the 15-LOX enzyme. All of the N. biserrata extracts (Nb-EtOH, Nb-Hex, Nb-EtOAc, and Nb-Aq) and the hexane-soluble partition (Ap-Hex) of A. palmiformis were found to be active and selective towards inhibition of the COX-2 enzyme. The observed anti-inflammatory activity of N. biserrata rhizome and A. palmiformis frond extracts suggests that N. biserrata rhizomes and A. palmiformis fronds are potential sources of natural anti-inflammatory components.
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