In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model
Paper Details
In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model
Abstract
The study in reference was planned to evaluate the anti-inflammatory, antipyretic and antinociceptive activities of methanolic extract of Himalrandia tetrasperma (MEHT), as well as acute toxicity. Anti-inflammatory, antipyretic, antinociceptive and acute toxicity activities were evaluated using mice animal model. Anti-inflammatory activity was investigated using carrageenan-induced edema model of inflammation. Brewer, s yeast induced pyrexia method was employed to evaluate the antipyretic activity. To assess the antinociceptive property of extract two models were employed, acetic acid-induced writhing model and hot plate model. Acute toxicity was conducted with the help of well-established method. The extract showed significant (p < 0.01) anti-inflammatory effect. The extract exhibited prominent (p < 0.01) antipyretic activity. It also evoked substantial (p < 0.01) anti-nociceptive activity (both peripheral and central analgesia). Acute toxicity data revealed that the extract was non-toxic up to a dose of 1500 mg/kg. From these findings it has been found that MEHT could be used to develop a natural drug to cure these ailments.
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Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Umar Rehman, Farah Gul (2020), In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model; IJB, V16, N3, March, P566-575
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