In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model

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Research Paper 01/03/2020
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In-vivo biological investigations of methanolic extract of Himalrandia tetrasperma in animal model

Yaqoob ur Rehman, Bashir Ahmad, Mushtaq Ahmad, Saad Ahmad Khan, Muhammad Idrees, Shafaatullah, Umar Rehman, Farah Gul
Int. J. Biosci.16( 3), 566-575, March 2020.
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The study in reference was planned to evaluate the anti-inflammatory, antipyretic and antinociceptive activities of methanolic extract of Himalrandia tetrasperma (MEHT), as well as acute toxicity. Anti-inflammatory, antipyretic, antinociceptive and acute toxicity activities were evaluated using mice animal model. Anti-inflammatory activity was investigated using carrageenan-induced edema model of inflammation. Brewer, s yeast induced pyrexia method was employed to evaluate the antipyretic activity. To assess the antinociceptive property of extract two models were employed, acetic acid-induced writhing model and hot plate model. Acute toxicity was conducted with the help of well-established method. The extract showed significant (p < 0.01) anti-inflammatory effect. The extract exhibited prominent (p < 0.01) antipyretic activity. It also evoked substantial (p < 0.01) anti-nociceptive activity (both peripheral and central analgesia). Acute toxicity data revealed that the extract was non-toxic up to a dose of 1500 mg/kg. From these findings it has been found that MEHT could be used to develop a natural drug to cure these ailments.


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