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Research Paper | November 1, 2012

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In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn.

Ashraf-ul Kabir, Ninadh Malrina D’Costa, Mehdi Bin Samad, JMA Hannan

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Int. J. Biomol. & Biomed.2(3), 1-7, November 2012

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Abstract

Ficus carica Linn is occasionally used in preparation of local traditional medicines used in the treatment of diarrhoea in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating antidiarrhoeal activity of F. carica Linn. Ethanolic extract of leaf and bark of F. carica Linn showed significant (p ≤ 0.05) decrease in the severity of diarrhoea, in a dose dependent manner, in castor oil induced diarrhoea test. Prostaglandin E2 induced intestinal fluid accumulation test (enteropooling) gave significant results (P ≤ 0.05), indicating possible antidiarrhoeal action. The extract produced significant (P ≤ 0.05) reduction of intestinal transit in gastrointestinal motility test with barium sulfate milk in healthy rats. It is evident that F. carica Linn have significant antidiarrhoeal activity and may be a potential source of antidiarrhoeal agents.

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In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn.

Agbor G, Leopold T, Jeanne N. 1999. The antidiarrhoeal activity of Alchornea cordefolia leaf extracts. Phytotherapy research 13, 292-295.

Aranda-Michel J, Gianella R. 1999. Acute diarrhoea: A practical review. American Journal of Medicine 106, 607-676.

Awouters F, Nimegeers C, Lenaerts F, Janssen P. 1978. Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis. Journal of Pharmacy and Pharmacology 30, 41-45.

Doherty NS. 1981. Inhibition of arachidonic acid release as the mechanism by which glucocorticoids inhibit endotoxin induced diarrhoea. British Journal of Pharmacology 73, 549-554.

Ecobichon, D. 1997. The Basis of ToxicologyTesting. New York: CRC Press.

Firenzuoli F, Gor L. 2007. Herbal Medicine Today: Clinical and Research Issues. Evidence Based Complementary and Alternative Medicine 4, 37-40.

Gaginella T, Stewart J, Olson W, Bass P. 1975. Actions of ricinoleic acid and structurally related fatty acid on the gastrointestinal tract II. Effects on water and electrolyte absorption in vitro. Journal of Pharmacology and Experimental Therapeutics 195, 355-361.

Galvez J, Crespo M, Jimerez J, Suarez A, Zarzuelo A. 1991. Antidiarrhoeic activity of Seleroarya birrea bark extraxt and its active tannin constituent in rat. Phytotherapy Resaerch 5, 276-278.

Oben J, Assi S, Agbor G, Musor D. 2006. Effect of Eremomastax speciosa on experimental diarrhoea. African Journal of Traditional Coplimentary and alternative Medicine 3 (1), 95-100.

Park K. 2000. Park’s Textbook preventive and social medicine. Jabalpur, India: M/S Banarsidas Bharat Publishers.

Patil VR, Patil VV. 2011. Ficus carica Linn-An Overview. Research Journal of Medicinal Plant 5 (3), 246-253.

Pierce N, Carpenter C, Elliott H, Greenough W. 1971. Effects of prostaglandins, theophylline and cholera exotoxin upon transmucosal water and electrolyte movement in canine jejunum. Gastroenterology 60, 22-32.

Shoba FG, Thomas M. 2001. Study of Antidiarrhoeal activity of four medicinal plants in castor oil induced diarrhoea. Journal of Ethnopharmacology 76 (1), 73-76.

Sofowor A. 1993. Medicinal plants and traditional medicine in africa. Ibadan: Spectrum Books.

Su Y, Leung L, Bi Y, Huang Y, Chen Z. 2000. Antioxidant activity of flavonoids isolated from Scutellaria rehderiana. Journal of American Chemical Society 77, 807-812.

Trease G, Evans W. 1996. Pharmacognosy. London: Bailliere Tindall.

Tylor V. 2000. Herbal Medicine: from the past to the future. Public Health Nutrition 3, 447-452.

Victoria  C,  Bryce J,  Fontaine O,  Monasc  R. 2000. Reducing deaths from diarrhoea through oral rehydrationtherapy. Bulletin of World Health Organization 78 (1), 1246-1255.

Werbach M. 1993. Healing with Food. New York: Harper Colines.

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