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In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn.

Research Paper | November 1, 2012

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Ashraf-ul Kabir, Ninadh Malrina D’Costa, Mehdi Bin Samad, JMA Hannan

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Int. J. Biomol. & Biomed.2( 3), 1-7, November 2012


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Ficus carica Linn is occasionally used in preparation of local traditional medicines used in the treatment of diarrhoea in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating antidiarrhoeal activity of F. carica Linn. Ethanolic extract of leaf and bark of F. carica Linn showed significant (p ≤ 0.05) decrease in the severity of diarrhoea, in a dose dependent manner, in castor oil induced diarrhoea test. Prostaglandin E2 induced intestinal fluid accumulation test (enteropooling) gave significant results (P ≤ 0.05), indicating possible antidiarrhoeal action. The extract produced significant (P ≤ 0.05) reduction of intestinal transit in gastrointestinal motility test with barium sulfate milk in healthy rats. It is evident that F. carica Linn have significant antidiarrhoeal activity and may be a potential source of antidiarrhoeal agents.


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In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn.

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