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Research Paper | December 7, 2022

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In-vivo study of cedar wood oil on the protective effects of hepatotoxicity, renal toxicity and hyperlipidemia

Yaqoob ur Rehman, Farah Gul, Muhammad Qaiser, Farina Kanwal, Mushtaq Ahmad, Numan Salehazada, Javed Bangash

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Int. J. Biosci.21(6), 341-347, December 2022

DOI: http://dx.doi.org/10.12692/ijb/21.6.341-347

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Abstract

Plants and plant-derived materials play an immensely vital role in disease management and health care programs. Essential oil from wood chips of Himalayan Cedar, Cedrus deodara (Roxburgh) family: Pinaceae), was obtained by hydrodistillation. The cedar wood oil at various test doses of 250mg/kg, 500mg/kg, and 1000mg/kg was evaluated for various activities like liver function tests, lipid profile, and renal function tests by using the in vivo mice model. The study’s bioassay results revealed the potential of cedar oil for its use in health management and its efficacy in treating high levels of Total Cholesterol (TC), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), Very Low-Density Lipoprotein (VLDL), ALP, AST, ALT, Bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), Urea (U) and Creatinine. In conclusion, Cedar wood oil can be an effective therapeutic agent against hepatotoxicity, renal toxicity, and hyperlipidemia. Furthermore, the detailed analysis of cedar wood oil will further explore the formulation of new medicinal plant-based drugs.

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In-vivo study of cedar wood oil on the protective effects of hepatotoxicity, renal toxicity and hyperlipidemia

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