In-vivo study of cedar wood oil on the protective effects of hepatotoxicity, renal toxicity and hyperlipidemia

Paper Details

Research Paper 07/12/2022
Views (684) Download (67)
current_issue_feature_image
publication_file

In-vivo study of cedar wood oil on the protective effects of hepatotoxicity, renal toxicity and hyperlipidemia

Yaqoob ur Rehman, Farah Gul, Muhammad Qaiser, Farina Kanwal, Mushtaq Ahmad, Numan Salehazada, Javed Bangash
Int. J. Biosci.21( 6), 341-347, December 2022.
Certificate: IJB 2022 [Generate Certificate]

Abstract

Plants and plant-derived materials play an immensely vital role in disease management and health care programs. Essential oil from wood chips of Himalayan Cedar, Cedrus deodara (Roxburgh) family: Pinaceae), was obtained by hydrodistillation. The cedar wood oil at various test doses of 250mg/kg, 500mg/kg, and 1000mg/kg was evaluated for various activities like liver function tests, lipid profile, and renal function tests by using the in vivo mice model. The study’s bioassay results revealed the potential of cedar oil for its use in health management and its efficacy in treating high levels of Total Cholesterol (TC), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), Very Low-Density Lipoprotein (VLDL), ALP, AST, ALT, Bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), Urea (U) and Creatinine. In conclusion, Cedar wood oil can be an effective therapeutic agent against hepatotoxicity, renal toxicity, and hyperlipidemia. Furthermore, the detailed analysis of cedar wood oil will further explore the formulation of new medicinal plant-based drugs.

VIEWS 141

Abarikwu SO, Njoku RCC, Onuah CL. 2018. Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats. Journal of Basic and Clinical Physiology and Pharmacology 29, 365-376.

Adaramoye OA, Akintayo O, Achem J and Fafunso MA. 2008. Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet. Vascular Health and Risk Management 4, 235.

Assmann G, Gotto JAM. 2004. HDL cholesterol and protective factors in atherosclerosis. Circulation 109, III-8-III-14.

Berk P, Noyer C. 1994. Clinical-chemistry and physiology of bilirubin. seminars in liver disease, thieme medical publ inc 381 park ave south, New York, Ny 10016.

Clark VL, Kruse JA. 1990. Clinical methods: the history, physical, and laboratory examinations. Jama 264, 2808-2809.

Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. 2000. Diagnosis and monitoring of hepatic injury. I. Performance Characteristics of Laboratory Tests. Clinical Chemistry 46, 2027-2049.

Fevery J, Blanckaert N. 1986. What can we learn from analysis of serum bilirubin. Journal of Hepatology 2, 113-121.

Fishman WH. 1990. Alkaline phosphatase isozymes: recent progress. Clinical Biochemistry 23, 99-104.

Ganda OP, Bhatt DL, Mason RP, Miller M, Boden WE. 2018. Unmet need for adjunctive dyslipidemia therapy in hypertriglyceridemia management. Journal of the American College of Cardiology 72, 330-343.

Giannini EG, Testa R, Savarino V. 2005. Liver enzyme alteration: a guide for clinicians. Cmaj 172, 367-379.

Green RM, Flamm S. 2002. AGA technical review on the evaluation of liver chemistry tests. Gastroenterology 123, 1367-1384.

Hammer KA, Carson CF, Riley TV. 1999. Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology 86, 985-990.

Irshad M, Subhani MA, Ali S, Hussain A. 2020. Biological importance of essential oils. Essential Oils-Oils of Nature 1.

Laufs U, Parhofer KG, Ginsberg HN, Hegele RA. 2020. Clinical review on triglycerides. European Heart Journal 41, 99-109c.

Liaqat I, Riaz N, Saleem QUA, Tahir HM, Arshad M, Arshad N. 2018. Toxicological evaluation of essential oils from some plants of Rutaceae family. Evidence-Based Complementary and Alternative Medicine 2018.

Marcello I. 2006. Hist-cytochemistry and scanning electron microscopy of lavender glandular trichomes following conventional and microwave-assisted hydrodistillution of essential oils: A comparative study. Flavour Fragr. J 21, 704-712.

Matsunaga T, Hasegawa C, Kawasuji T, Suzuki H, Saito H, Sagioka T, Takahashi R, Tsukamoto H, Morikawa T, Akiyama T. 2000. Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica. Biological and Pharmaceutical Bulletin 23, 595-598.

Nisha R, Srinivasa Kannan S, Thanga Mariappan K, Jagatha P. 2017. Biochemical evaluation of creatinine and urea in patients with renal failure undergoing hemodialysis. J. Clin. Path. Lab. Med, 1, 1-5.

Nofer JR, Kehrel B, Fobker M, Levkau B, Assmann G, von Eckardstein A. 2002. HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis 161, 1-16.

Ramadass M, Thiagarajan P. 2015. Importance and Applications of Cedar oil. Research Journal of Pharmacy and Technology 8, 1714-1718.

Röhrl C, Stangl H. 2013. HDL endocytosis and resecretion. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1831, 1626-1633.

Sharma U, Pal D, Prasad R. 2014. Alkaline phosphatase: an overview. Indian Journal of Clinical Biochemistry 29, 269-278.

Wald N, Law M. 1995. Serum cholesterol and ischaemic heart disease. Atherosclerosis 118, S1-S5.

Walker HK, Hall WD, Hurst JW. 1990. Clinical methods: The History, Physical and Laboratory Examinations.

Wróblewski F. 1958. The clinical significance of alterations in transaminase activities of serum and other body fluids. Advances in Clinical Chemistry 1, 313-351.