In vivo study of stress oxidative and some organs damage in rats exposed to metribuzin (triazinone herbicide)

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Research Paper 01/12/2019
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In vivo study of stress oxidative and some organs damage in rats exposed to metribuzin (triazinone herbicide)

Mahboub Nasma, Slimani Noureddine, Salhi Imane, Adaika Aicha, Khelil Aminata
Int. J. Biosci.15( 6), 397-404, December 2019.
Certificate: IJB 2019 [Generate Certificate]
Key: Metribuzin


The study was conducted to investigate the effects of pesticides Metribuzin (Triazinone herbicide) which is used worldwide as an ecotoxic herbicide and is the most widely used in Algeria and in random ways without respect for the doses approved, on oxidative stress and liver structure in rats. About 30 female rats Wistar albinos divided into five groups (n=6), the first group of non-treated rats serve as control, the second group of rats treated with 30 mg kg–1 b.wt., of Metribuzin and the third group of rats treated with 30 mg kg–1 b.wt. of Metribuzin followed by aqueu extrcts of Astragalus gombo (roots) with dose 80 mg/kg during 15 days, the fourth group treated with 30 mg kg–1 b.wt. of Metribuzin followed by aqueu extrcts of Astragalus gombo (leaves) with dose 60 mg/kg during 15 days and the fifth group of rats treated with 30 mg kg–1 b.wt. of Metribuzin, followed by drug (vitamin E) with dose 200 mg/ml. Metribuzin added in their drinking water for 30 days. This plant administered in combination with the pesticide shows a highly significant decrease (p≤0.01) in maintaining the equilibrium of the antioxidant/prooxidant balance cells of all tissues studied. The treatment with the two extracts of Astragalus gombo decreases the state of oxidative stress induced by metribuzin exposure by limiting free radical phenomena and repairing oxidative damage by decreasing lipid peroxidation in the liver, kidney and liver.


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