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Incidence of anesthetics drug induced malignant hyperthermia in Lady Reading Hospital (LRH), Peshawar, Pakistan

Research Paper | July 1, 2020

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Muhammad Tayyeb, Muhammad Ali, Sher Muhammad, Bashir Ul Haq, Arsalan Khan, Muhammad Qasim Jan, Muhammad Abbas

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Int. J. Biosci.17( 1), 232-237, July 2020

DOI: http://dx.doi.org/10.12692/ijb/17.1.232-237


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Malignant hyperthermia (MH) is a pharmacogenetic disorder and life-threatening syndrome of skeletal muscle with exposure to potent inhalational anesthetics (Halothane, desflurane) and depolarizing muscle relaxant (succinylcholine). To determine the incidence of anesthetic drug induced malignant hyperthermia in patients in lady reading hospital Peshawar. This cross-sectional study was carried out in duration of six months (February to August 2019) in lady reading hospital (LRH) Peshawar. The intension of this study was to determine the incidence of drug induced (MH) in patients who are going for surgical procedure under general anaesthesia especially exposure to inhalational agents and Suxamethonium. Ethical approval was taken from ethical committee of Khyber Medical University (KMU) and Leady Reading Hospital (LRH) Peshawar. Informed consent was taken from Participants. Demographics details and patient’s data were recorded and analysed through SPSS. Data of 424 patients were obtained in which males were 268 (63.2%) and female were 156 (36.8%). The mean age of the patients was 31.2±19.4. There was no case of malignant hyperthermia among these patients. The pinpoint incidence of malignant hyperthermia is unknown. In our study we are not find any case of malignant hyperthermia.


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Incidence of anesthetics drug induced malignant hyperthermia in Lady Reading Hospital (LRH), Peshawar, Pakistan

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