Increased Immunoglobulin E is associated with low respiratory functional in asthma patients

Paper Details

Research Paper 01/12/2011
Views (381) Download (8)

Increased Immunoglobulin E is associated with low respiratory functional in asthma patients

Eizadi Mojtaba, Seyed Hoseini MohammadAli, Khorshidi Davood, Dooaly Hussein
J. Bio. Env. Sci.1( 6), 214-220, December 2011.
Certificate: JBES 2011 [Generate Certificate]


Asthma is a disease that is associated with inflammation airway. The study objective was to determine whether the serum Immunoglobulin E (IgE) concentration was associated with marker indicative in respiratory functional in men with asthma. For this purpose, we measured fasting serum IgE levels in 44 middle-aged men with mild to moderate asthma and 30 none-asthma subject that matched for age and sex. In addition, all patients underwent a resting spirometry test for measuring FEV1, FVC and FEV1/FVC as markers indicative in respiratory functional. Pearson correlations were used to establish the relationship between IgE concentrations with spirometry markers in asthma patients. A p-value < 0.05 was considered to be statistically significant. The statistical findings showed that an IgE concentration in asthmatic patients was significantly higher than healthy individuals. Compared with healthy subjects, asthma patients had lower level of FEV1, FVC and FEV1/FVC. A negative association was observed between serum IgE and FEV1, FVC and FEV1/FVC.Based on this data, it was concluded that IgE may be a precise predictor of asthma diagnosis.


Anupama N, Vishnu Sharma M, Nagaraja HS. 2005. Ramesh BhatThe serum immunoglobulin E level reflects the severity of bronchial asthma. American review of respiratory disease 18 (3), 35-40.

Arshad SH, Holgate S. 2001. The role of IgE in allergen-induced inflammation and the potential for intervention with a humanized monoclonal anti-IgE antibody. Clinical & Experimental Allergy 31(9), 1344-51.

Barnes PJ, Chowdhury B, Kharitonov SA, Magnussen H, Page CP, Postma D et al. 2006. Pulmonary biomarkers in COPD. Am J Respir Crit Care Med 174, 6–14.

Bousquet J, Vignola AM, Demoly P. 2003. Links between rhinitis and asthma. Allergy 58, 691–706.

Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. 1989. Association of asthma with serum IgE levels and skin-test reactivity to allergens. New England Journal of Medicine 320(5), 271-277.

Buses WW, Lemanske RF. 2001 Asthma. New England Journal of Medicine 344(3), 350–362.

Chawes BL, Kreiner-Møller E, Bisgaard H. 2010. Upper and Lower Airway Patency are Associated in Young Children. Chest 137(6), 1332-7.

Chowdary V S, Vinaykumar E C, Rao J J, Ratna Rao, Ram Babu K, and Rangamani V. 2003. A study on serum IgE and eosinophils in respiratory allergy patients. Indian J Allergy Asthma Immunol 17, 21-24.

Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. 2003. Airway remodeling in asthma: new insights. Journal Allergy Clinical Immunology 111, 215–225.

Elias JA, Zhu Z, Chupp G, Homer RJ. 1999. Airway remodeling in asthma. Journal of Clinical Investigation 104, 1001–1006.

Freidhoff LR, Marsh DG. 1993. Relationship among asthma, serum IgE levels, and skin test reactivity to inhaled allergens. International Archive Allergy Applied Immunology 100, 355– 361.

Ishizaka T, Ishizaka K. 1984. Activation of mast cells for mediator release through IgE receptors. Prog Allergy 34(2) 188-235.

Leung DYM. 1997. Immunologic basis of chronic allergic disease: clinical messages from the laboratory bench. Pediatric Respiratory 42, 559– 568.

Leung DYM. 1998. Molecular basis of allergic disease. Molecular Genetics and Metabolism 63, 157–167.

MacGlashan Jr D, Lichtenstein LM, McKenzie-White J. 1999. Upregulation of FcepsilonRI on human basophils by IgE antibody is mediated by interaction of IgE with FcepsilonRI. Journal Allergy Clinical Immunology 104, 492–8.

MacGlashan Jr DW, Bochner BS, Adelman DC, Jardieu PM, Togias A, Lichtenstein LM. 1999. Serum IgE level drives basophil and mast cell IgE receptor display. International Archive Allergy Applied Immunology 113, 45–7.

Mannino  DM,  Ford  ES,  Redd  SC.  2003. Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination. American Journal of Medicine 114(9), 758–762.

Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM & Galli SJ. 1993. Mast cell activation enhances airway responsiveness to methacholine in the mouse. Journal of Clinical Investigation 91, 1176-1182.

Mayr SI, Zuberi RI, Liu FT. 2003. Role of immunoglobulin E and mast cells in murine models of asthma. Brazilian Journal of Medical and Biological Research 36(7), 821-7.

Nowak D. 2006. Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab. Respiratory Medicine 100, 1907– 1917.

Platts-Mills TA. 2001. The role of immunoglobulin E in allergy and asthma. American Journal of Respiratory and Critical Care Medicine 164, S1–5.

Schroeder EB, Welch VL, Couper D, Nieto FJ, Liao D, Rosamond WD. 2003. Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. American Journal of Epidemiology 158, 1171–1181.

Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, and Holdaway MD. 1993. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. New England Journal of Medicine 325, 1067-1071.

Sin DD, Man SF. 2003. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 107(11), 1514–1519.

Sin DD, Wu L, Man SF. 2005. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest 127(6), 1952–1959.

Sutton BJ, Gould HJ. 1993. The human IgE network. Nature 366, 421–8.

Tollerud  DJ,  O’Connor  GT,  Sparrow  D, Weiss ST. 1991. Asthma, hay fever, and phlegm production  associated  with  distinct  patterns  of allergy skin test reactivity, eosinophilia, and serum IgE levels: the Normative Aging Study. American Review Respiratory Diseases 144, 776–781.

Winter WE, Hardt NS, Fuhrman S. 2000. Immunoglobulin E, importance in Parasitic Infections and Hypersensitivity Responses. Archives  of  Pathology  &  Laboratory  Medicine 124(9), 1382-5