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Research Paper | December 1, 2011

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Increased Immunoglobulin E is associated with low respiratory functional in asthma patients

Eizadi Mojtaba, Seyed Hoseini MohammadAli, Khorshidi Davood, Dooaly Hussein

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J. Bio. Env. Sci.1(6), 214-220, December 2011


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Asthma is a disease that is associated with inflammation airway. The study objective was to determine whether the serum Immunoglobulin E (IgE) concentration was associated with marker indicative in respiratory functional in men with asthma. For this purpose, we measured fasting serum IgE levels in 44 middle-aged men with mild to moderate asthma and 30 none-asthma subject that matched for age and sex. In addition, all patients underwent a resting spirometry test for measuring FEV1, FVC and FEV1/FVC as markers indicative in respiratory functional. Pearson correlations were used to establish the relationship between IgE concentrations with spirometry markers in asthma patients. A p-value < 0.05 was considered to be statistically significant. The statistical findings showed that an IgE concentration in asthmatic patients was significantly higher than healthy individuals. Compared with healthy subjects, asthma patients had lower level of FEV1, FVC and FEV1/FVC. A negative association was observed between serum IgE and FEV1, FVC and FEV1/FVC.Based on this data, it was concluded that IgE may be a precise predictor of asthma diagnosis.


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