Increased interleukin-1 beta is associated with high fasting glucose in obese men

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Research Paper 01/12/2011
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Increased interleukin-1 beta is associated with high fasting glucose in obese men

Eizadi Mojtaba, Khorshidi Davood, Seyedhoseini MohammadAli, Dooaly Hussein
Int. J. Biosci.1( 6), 141-146, December 2011.
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Interleukin-1 beat, a proinflammatory cytokine, plays important roles in systemic inflammation. The aims of present study were 1) to compare serum IL-1b between obese and none-obese me, 2) to determine serum IL-1b in relation to fasting glucose, insulin and beta-cell function in obese men. For this purpose, Venous blood samples were obtained after a overnight fast in order to measuring Il-1b, insulin, glucose in sedentary obese (30 ≤ BMI ≤ 36, n = 41) and none-obese (20 ≤ BMI ≤ 25, n = 36) men matched for age (370 ± 5, aged). Anthropometrical indexes were also monitored in two groups. Beta cell-function (HOMA-BF) was calculated by fasting insulin and glucose. Statistical analysis was performed by Independent sample T-test and Spearman rank correlation method. P value of <0.05 was accepted as significant. Serum IL-1b and glucose concentrations were significantly higher in obese men when compared with none-obese subjects (p < 0.05). Beat-cell function in obese men was lower than none-obese men (p < 0.05). IL-1b correlated negatively with the insulin and beta-cell function and positively with fasting glucose in obese men (p < 0.05). Based on this data, it was concluded that obesity is associated with systemic inflammation and Measurement of inflammatory indices may be represented glucose homeostasis in this population.


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