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Increased respiratory functional by aerobic training is independent of serum IgE in asthmatic patients

Research Paper | February 1, 2011

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Eizadi Mojtaba, Shahgholiabasi Rose, Iranshahi Farzaneh, Daraei Shokrabad Firooz

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J. Bio. Env. Sci.1( 1), 51-65, February 2011


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Chronic airway inflammation is often associated with increased Circulating levels of Immunoglobulin E (IgE). The aims of present study were 1) to evaluate the effect of aerobic exercise training on serum IgE in asthma patients, 2) to determine relationship between serum IgE and respiratory functional before and after exercise program in these patients. For this purpose, 32 adult males with asthma participated in this study and divided to exercise and control groups by randomly. Fasting serum IgE and some markers indicative of respiratory functional (FEV1, FVC, and FEV1/FVC) were measured before and after an aerobic exercise program (60 min, 3 days/week for 3 months) in two groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test. Pearson correlation method used to determine the relationship between serums IgE with spirometry markers in differ condition. At baseline, a significant negative correlation was found between serum IgE with each of spirometric markers (P<0.05). Compared to pre-training, respiratory functional increased significantly (p˂0.05) after exercise program but serum IgE was not changed. There were no correlations between serum IgE concentrations and spirometric markers after exercise program in exercise group (p≥0.05). All variables remained without change in control group (p≥0.05). Considering to these findings, our study supports of IgE as effective factor in asthma and we can say IgE levels is a strong predictor of allergy in asthmatic patients. But despite this close association, increased respiratory functional by exercise training is independent of serum IgE in these patients.


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Increased respiratory functional by aerobic training is independent of serum IgE in asthmatic patients

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