Indian ginseng (N.Hexane and Chloroform extracts) offers ameliorating effects on muscle functions restoration in a mouse model of peripheral nerve injury
Paper Details
Indian ginseng (N.Hexane and Chloroform extracts) offers ameliorating effects on muscle functions restoration in a mouse model of peripheral nerve injury
Abstract
Peripheral nerve injuries fall among most commonly happening medical situations nowadays. Such injuries occur in response to gunshots, road traffic accidents, mechanical crushes and traumas which eventually result into compromised sensory and motor activities. Despite having wonderful advancements in pharmacological therapies, such injuries are still waiting for their first line treatment. The present study is planned to assess the effect of n.Hexane and Chloroform extract of Indian ginseng root on sensorimotor function revival in mice induced with sciatic nerve crush lesion. Twelve male BALB/C mice were divided into control and 2 treatment groups having an equal number of mice (n=4) per group. Control was offered routine diet, while treatment groups (n.Hexane and Chloroform) were offered diet mixed with their respective treatments (100mg/kg daily dose of each extract of Indian ginseng root) from the day of the nerve crush and then until the end of the trial. Motor and sensory functions retrieval was assessed through sciatic functional index, grip strength, and hot plate tests which were found to be highly significant for Chloroform treated group. This group also showed prominent increase in skeletal muscle mass. The significant reduced (p=0.01) total oxidant status and increased total antioxidant capacity (p=0.01) in this group suggest that Indian ginseng root’s Chloroform extract has prominent potential for ameliorating the muscle function restoration as compared to control and n-Hexane group.
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