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Research Paper | September 10, 2022

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Inhibition of xanthine oxidase activity from extracted Agathis philippinensis (Almaciga), Tabernaemontana pandacaqui (Banana bush), and Cymbopogon citratus (Lemon grass)

Michelle Beatriz V. Iringan, Kimberly Mae M. Montenegro, Jane R. Sambrana, Ramelo Jr. B. Ramirez

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J. Bio. Env. Sci.21(3), 35-40, September 2022

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Abstract

Xanthine oxidase is a terminal enzyme for the breakdown of both hypoxanthine and xanthine to uric acid which has an essential role in conditions like hyperuricemia and gout. The “Malaueg” Community of Rizal, Cagayan identified Tabernaemontana pandacaqui (Banana bush) as having wound healing properties and Agathis philippinensis (Almaciga) and Cymbopogon citratus (Lemon grass) capable of easing arthritis. This study determined the phytochemical profiles of the plants and xanthine oxidase inhibition (XOI) potentials using UV-Vis spectrophotometer. The aqueous extract of the plants was screened for the presence of phytochemicals. A. philippinensis showed slightly active signals for flavonoids and tannins. T. pandacaqui showed active signals for coumarins, flavonoids, and tannins and very active signals for saponins. C. citratus showed slight active signals for tannins, active signals for flavonoids and very active signals for coumarins. The aqueous extracts were used for xanthine oxidase inhibition. Aqueous extracts of T. pandacaqui, C. citratus, and A. philippinensis elicited an XOI percentages of 57.53 ±4.169, 54.96 ± 3.030, and 22.63 ±0.7898, respectively. The positive control, Allopurinol obtained a percentage inhibition of 88.82 ±1.507. T. pandacaqui and C. citratus are potential herbal plants for xanthine oxidase inhibition and for drug discovery.

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Inhibition of xanthine oxidase activity from extracted Agathis philippinensis (Almaciga), Tabernaemontana pandacaqui (Banana bush), and Cymbopogon citratus (Lemon grass)

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