Interleukin-1 beta is increased in presence of type 2 diabetes in addition to adiposity level

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Research Paper 01/07/2012
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Interleukin-1 beta is increased in presence of type 2 diabetes in addition to adiposity level

Ahmadi Pezhman, Torabi Mohsen, Aran Ardabili Akbar, Aghazadeh Javad
Int. J. Biosci.2( 7), 104-111, July 2012.
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A large body of evidence suggests an inflammatory process; characterized by adipokines production regulates islet dysfunction and insulin resistance in type 2 diabetes. The present study is an attempt to find if serum IL-lb in diabetic subjects is increased with obesity, or diabetes disorder independent of body weight and fat level affects serum levels of this cytokines. For this purpose, fasting serum IL-1b and markers indicative of type 2 diabetic such as glucose, insulin resistance and Beta-cell function were measured in middle-aged obese men with type 2 diabetic (n=16) and those without diabetic (n=16) matched for age (38 ± 5, aged) in order to compare them between two group. Anthropometrical measurements were also performed of two groups. Diabetic patients have higher fasting glucose, insulin resistance and lower beta cell function than none-diabetic subjects. Serum IL-1b in diabetic patients was also significantly higher than none-diabetic subjects. Although participants of both diabetic and non diabetic groups were classified as obese, serum IL-1b in diabetic patients was higher than another group. Based on these data, we can say the presence of diabetes affect serum IL-1b independent of body fat levels or adiposity.


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