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Intra nasal in-situ gel freighted with Nano naturaceuticals for neurological diseases – from bench to bed side

Indira Muzib Yallamalli, Arunakumari Dommaraju, Ramji Ambedkar Yellamelli

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Int. J. Biosci.22(2), 156-170, February 2023

DOI: http://dx.doi.org/10.12692/ijb/22.2.156-170


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The treatment for acute or chronic neurodegenerative diseases is the most exigent aspect in many aspects, as the drug should cross the blood-brain barrier. At present many formulations have been developed for synthetic drugs to target the drug to the brain through various routes. Among them,the nasal route is one of the most prominent routes to target the drug to the brain, where the drug can bypass the BBB. There are many natural drugs, Phytoconstituents also available for the treatment of neurodegenerative diseases. Because of the many advantages like natural, safe, easily available, biocompatible, low cost, etc., of natural drugs over synthetic drugs, the researchers were focused on the development of the formulations of natural drugs for various diseases. But here, the challenging concept is the delivery of the active Phytoconstituents to the brain through the nasal route as the molecular weight of the drugs is rate limited. Among the nasal formulations, in-situ gel systems are the trending research work carrying. So the review was focused on the overview of the available Phytoconstituents to treat brain disorders and how the drugs target the brain through the nasal route. A brief about nasal anatomy, the pros and cons of nasal drug delivery and nasal in-situ gels was also noted. The review summarizes the available nanoformulations for the Phytoconstituents to target the drug to the brain through the nasal route.


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Intra nasal in-situ gel freighted with Nano naturaceuticals for neurological diseases – from bench to bed side

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