Invasive fungal infections and patients with malignancies in upper Egypt

Paper Details

Research Paper 01/11/2016
Views (501) Download (16)
current_issue_feature_image
publication_file

Invasive fungal infections and patients with malignancies in upper Egypt

Mohamed F. Awad, Ahmed Mustafa Abdel-Hadi, Usama M. Abdulraouf, Eman M. Zaki, Mohamed H Mohamed
Int. J. Micro. Myco.4( 4), 1-13, November 2016.
Certificate: IJMM 2016 [Generate Certificate]

Abstract

The incidence of invasive fungal infections has increased considerably in recent years. The aim of this study was to present a suitable early diagnostic procedure in immune compromised patients, using detection of fungal infection of urine samples collected from 33 patients with malignancies (from 2-89 years old), during the period from December 2012 to February 2014, from South Egypt. Fifty-three fungal species representing 14 genera were collected during this investigation from urine samples on Sabouraoud’s Dextrose Chloramphenicol Agar (46 species and 12 genera) and Rose Bengal Chloramphenicol Agar media (41 species and 11 genera). Aspergillus (16 species), Penicillium (14 species), Yeasts (5 species) and Cladosporium (5 species) contributed the broadest spectra of species in all samples tested on two types of media used. Other species were represented by 13 species belonging to 10 genera. The results indicate that immune compromised patient is a suitable habitat for the growth and sporulation of different groups of fungi, both saprophytic and pathogenic. A variety of types of filamentous fungi were obtained from malignancies patients. Immunosuppressant patient’s exposure for fungal infection so should be in especial care from food, drinking and air.

VIEWS 34

Assiut University Mycological Center. Assuit. Egypt. 2014; 71516.

Bodey GP, Mardani M, Hend A Hanna HA,, Boktour M, Abbas J, Girgawy E, Hachem RY, Dimitrios P, Kontoyiannis DP, Raad II. 2002. The epidemiology of Candida glabrata and Candida albicans fungemia in immune compromised patients with cancer American Journal of Medicine 112(5), 380-385.

Brown GD, Denning DW, Levitz SM. 2012.Tackling  human  fungal  infections.  Science 336 (6082), 647.

Buitkamp J, Zischler H, Epplen JT, Geldermann H. 1991. DNA fingerprinting in cattle using oligonucleotide probes. Animal Genetics 22, 137-146.

Cornely OA, Maertens J, Winston DJ, Perfect J, Ullmann AJ, Walsh TJ, Helfgott D, Holowiecki J, Stockelberg D, Goh YT, Petrini, MD, Cathy Hardalo MD, Suresh R, Angulo-Gonzalez MD. 2007. Posac-onazole vs. fluconazole or Iitraconazole prophylaxis in patients with neutropenia. The New England Journal of Medicine 356(4), 348-359.

Cornely OA, Gachot B, Akan H, Bassetti M, Uzun O, Kibbler C, Marchetti O, Bille J, de Burghgraeve P, Ramadan S, Pylkkanen L, Ameye L, Paesmans M, Donnelly PJ. 2015. Epidemiology and outcome of fungemia in a cancer Cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031). Clinical Infection Diseases 61(3), 324-31.

Del Bono V, Mikulska M, Viscoli C. 2008. Invasive aspergillosis: diagnosis, prophylaxis and treatment. Journal of Current opinion in hematology 15(6), 586-593.

EL-mahallawy HA, Attia I, Ali-El-Din NH, Salem AE, Abo-EL-naga S. 2002. Prospective study on fungal infection in children with cancer Journal of Medical Microbiology 51(7), 601-605.

Fourneret-Vivier A, Lebeau B, Mallaret MR, Brenier-Pinchart MP, Brion JP, Pinel C, Garban F, Pison C, Hamidfar R, Plantaz D, Pelloux H, Grillot R. 2006. Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). Journal of Hospital Infection 62(1), 22-28.

Girmenia C, Pagano L, Martino B, D’Antonio D, Fanci R, Specchia G, Melillo L, Buelli M, Pizzarelli G, Venditti M, Martino P, the GIMEMA Infection Program. 2005. Invasive infections caused by Trichos poron species and Geotrichum capitatum in patients with hematological malignancies: A retrospective multicenter study from Italy and review of the literature. Journal Clinical Microbiology 43(4), 1818-1828.

Hachem RY, Kontoyiannis DP, Boktour MR, Afif C, Cooksley C, Bodey GP, Chatzinikolaou I, Perego C, Hagop M, Kantarjan MD. 2004. Aspergillus terreus: an emerging amphotericin B-resistant opportunistic mold in patients with hematologic malignancies. Journal of Cancer 101(7), 1594-1600.

Hachm R, Hanna H, Kontoyiannis D, Ying Jiang Y, Raad I. 2008. The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancy. Cancer 112(11), 2493-2499.

Kauffman CA, Gerald L, Mandell GL. 2006. Atlas of Fungal Infection, Current Medicine Group; 2nd edition, (ISBN. 978-1-57340-242-2 Springer), 280.

Kawin EN, Anaissie EJ. 1999. Dematiaceous and non-pigmented fungi: invasive and systemic disease.in: VL Yu, TC Merigan, SL Barriere (Eds.) Antimicrobial Therapy and Vaccines. Williams &Wilkins, Baltimore MD 1, 1102-1109.

Kontoyiannis DP, Lionakis MS, Lewis RE, Chamilos G, Healy M, Perego C, Safdar A, Kantarjian H, Champlin R, Walsh TJ, Raad II. 2005. Zygomycosis in a tertiary care cancer center in the era of Aspergillus active antifungal therapy: A case-control observational study of 27 recent cases. Journal of Infection Diseases 19(8), 1350-1360.

Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG. 2010. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001–2006: overview of the Transplant Associated Infection Surveillance Network (TRANSNET) database. Clinical Infectious Diseases 50(8), 1091-100.

Kradin RL, Mark EJ. 2008. The Pathology of Pulmonary Disorders Due to Aspergillus spp. Archives of Pathology and Laboratory Medicine 132(11), 1713-1714.

Maschmeyer G, Haas A, Cornely OA. 2007. Invasive aspergillosis Epidemiology, diagnosis and management in immune compromised patients. Journal of Drugs 67(11), 1567-1601.

Menichetti F, Del Favero A, Martino P. 1998. Risk factors for infections in hematological malignancies. Reviews in clinical and experimental hematology 7, 3-22.

Mora C, Tittensor DP, Adl S, Simpson AG, Worm B. 2011. How many species are there on Earth and in the ocean? PLoS Biology 9(8), 1-8.

Morgan J, Wannemuehler KA, Marr KA, Hadley S, Komtoyiannis DP, Walsh TJ, Fridkin SK, Pappas PG, Warnock DW. 2005. Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim results of a prospective multicenter surveillance program. Journal of Medical Mycology 43(1), 49-58.

Moubasher AH. 1993. Soil fungi of Qatar and other Arab Countries, (ISBN-10: 9992121025. The Scientific and Applied Research Centre. Doha, Qatar: University of Qatar) 566.

Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B, Pastore D, Picardi M, Bonini A, Chierichini A, Fanci R, Caramatti C, Invernizzi R, Mattei D, Mitra ME, Melillo L, Aversa F, Van Lint MT, Falcucci P, Valentini CG, Girmenia C, Nosari A. 2006. The epidemiology of fungal infections in patients with hematologic malignancies: The SEIFEM-2004 study. Haematologica 9(8), 1068-1075.

Pagano L, Caira M, Candoni A, Offidani M, Martino B, Specchia G, Pastore D, Stanzani, M, Cattaneo C, Fanci R, Caramatti C, Rossini F, Offidani M, Luppi M, Potenza L, Felicetto Ferrara F, Mitra MF, Fadda RM, Invernizzi R, Aloisi T, Picardi M, Bonini A, Vacca A, Chierichini A, Melillo L, de Waure C, Fianchi L, Riva M, Leone G, Aversa F, Nosari A. 2010. Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study. Haematologica 95(4), 644-650.

Pagano L, Offidani M, Fianchi L, Nosari A, Candoni A, Piccardi M, Corvatta L, D’Antonio D, Girmenia C, Martino P, Del Favero A, GIMEMA (Gruppo Italiano Malattie E, Matologiche dell’ Adulto) Infection Program. 2004. Mucormycosis in hematologic patients. Haematologica 89(2), 207-214.

Pappas PG, Kauffman CA, Andes D, Daniel K, Benjamin DK, Jr, Calandra TF, Edwards JE, Jr, John E, John F, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobe JD. 2009. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clinical Infection Diseases 48(5), 503-535.

Patterson TF, Kirkpatrick WR, White M, Hiemenz JW, Wingard JR, Dupont B, Rinaldi MG, Stevens DA, Graybill JR. 2000. Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group. Medicine (Baltimore) 79, 250-260.

Pfaller MA, Diekema DJ. 2004. Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus. Journal of Clinical Microbiology 42(10), 4419-4431.

Pitt JI, Hocking AD. 2009. Fungi and food spoilage. (ISBN: 978-0-387-92206-5. Springer Dordrecht Heidelberg London: New York) 519.

Rath PM, Ansorg R. 1997. Value of environmental sampling and molecular typing of aspergilli to assess nosocomial sources of aspergillosis. Journal of Hospital Infection 37(1), 47-53.

Romani L. 2008. Cell-mediated immunity to fungi: a reassessment. Medical Mycology 46(6), 515-529.

Ruangritchankul K., Chindamporn A, Worasilchai N, Poumsuk U, Keelawat S. 2015. Invasive fungal disease in university hospital: a PCR-based study of autopsy cases. International Journal Clinical Experimental Pathology 8(11), 14840-52.

Ruping MJ, Vehreschild JJ, Cornely OA. 2008. Patients at high risk of invasive fungal infections: when and how to treat. Drugs 68(14), 1941-1962.

Scherer S, Stevens DA. 1987. Application of DNA typing methods to epidemiology and taxonomy of Candida species. Journal Clinical Microbiology 25(4), 675-9.

Segal BH. 2008. Aspergillosis. New England Journal of Medicine 360, 1870-1884.

Takahashi T. 1997. Airborne fungal colony-forming units in outdoor and indoor environments in Yokohama, Japan. Mycopathologia 139(1), 23-33.

Vehreschild JJ1, Rüping MJ, Wisplinghoff H, Farowski F, Steinbach A, Sims R, Stollorz A, Kreuzer KA, Hallek M, Bangard C, Cornely OA. 2010. Clinical effectiveness of posaconazole prophylaxis in patients with acute myelogenous leukaemia (AML): a 6 year experience of the Cologne AML cohort. Journal of Antimicrobial Chemotherapy 65(7), 1466-1471.

Walsh TJ, Groll A, Hiemenz J, Fleming R, Roilides E, Anaissie E. 2004. Infections due to emerging and uncommon medically important fungal pathogens. Journal of Clinical Microbiology Infection 10(1), 48-66.

Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Segal BH,, Steinbach WJ, Stevens DA, Van Burik J, Wingard JR, Patterson TF. 2008. Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America. Journal of ClinicalInfectious Diseases 46(3), 327-360.

White TJ, Burns T, Lee S, Taylor J. 1990. Amplification and sequencing of fungal ribosomal RNA genes for phylogenetics. In PCR protocols. A guide to methods and applications. Eds Innis M. A. Gelfand D. H., Sninsky J. J., White T. J. (Academic Press, Inc. San Diego, Calif) 315-322.

Wingard JR. 1995. Importance of Candida species other than Candida albicans as pathogens in oncology patients. Journal of Clinical Infectious Diseases 20(1), 115-125.