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Investigation of liver function tests (LFTs) and renal function tests (RFTs) in pregnant women affected with hypertensive disorders of pregnancy (HDP)

Research Paper | May 1, 2019

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Haleema Sadia, Rafia Batool, Rubina Mansoor, Bilal Qureshi, Sana Ashiq, Asma Irshad, Muhammad Riaz, Kanwal Ashiq

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Int. J. Biosci.14( 5), 86-94, May 2019

DOI: http://dx.doi.org/10.12692/ijb/14.5.86-94


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Hypertensive disorders of pregnancy (HDP) are major health burdens in obstetric population and almost 12-22% pregnancies are affected by HDP in the world. In patients with HDP, liver and renal functions abnormality can negatively affect both maternal and fetal health. The present study was performed to compare changes of liver and renal functions in pregnant women suffering with hypertensive disorders. Blood samples of 200 patients who attended the Holy Family Hospital, Rawalpindi were collected randomly and were checked for LFTs and RFTs. Automated chemical analyzer (Beckmann Colter or Selectra) was used; some samples were also quantified by Microlab-300 manually. Out of these 200 patients, 90 (45%), 59 (29.5%),16 (8%), 11 (5.5%) and 24 (12%) women were diagnosed with the Gestational HTN, Pre-eclampsia, Chronic HTN, Pre-eclampsia superimposed on Chronic HTN and Eclampsia respectively. Total bilirubin, ALT and ALP were increased in 60 (30%), 59 (29.5%) and 85 (42.5%) samples respectively while urea, creatinine and uric acid were increased in 46 (23%), 49 (24.5%) and 91 (45.5%) patients, respectively. Almost 75% patients had 31-40 weeks gestational period, 83% patients had no pre- history and 73% had no family history. Almost, 95 % HDP patients were between 17-40 years. Mortality and morbidity rate is higher in developing countries including Pakistan. So, it is recommended to perform the regular examination of LFTs and RFTs in the HDP patients because early diagnosis and treatment can eradicate the risk of mortality of mother and fetus.


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Investigation of liver function tests (LFTs) and renal function tests (RFTs) in pregnant women affected with hypertensive disorders of pregnancy (HDP)

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