Is antibacterial PNA the answer for combating multidrug resistant bacterial infections?
Paper Details
Is antibacterial PNA the answer for combating multidrug resistant bacterial infections?
Abstract
The emergence of multidrug resistant bacterial infections is a serious problem. Treatment options are limited to patients those are infected with multidrug resistant bacteria. We are in a desperate need of new antibiotics. Antisense oligomers of PNA (Peptide Nucleic Acid) were introduced in late 90’s as antibacterial agents in an intention to create a new class of bacterial specific antibiotic. Followed by several studies have demonstrated that antibacterial PNA oligomers are effective in a verity of pathogenic bacterial strains. Development of PNA-based drugs (PNA antibiotics) will help us to combat infections of drug resistant bacterial strains.
Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. 2005. Host-bacterial mutualism in the human intestine. Science. 307(5717), 1915–20. http://dx.doi.org/10.1126/science.1104816
Bai H, You Y, Yan H, Meng J, Xue X, Hou Z, Zhou Y, Ma X, Sang G, Luo X. 2012. Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene. Biomaterials. 33(2), 659–67.
Fritz JV, Heintz-Buschart A, Ghosal A, Wampach L, Etheridge A, Galas D, Wilmes P.2016. Sources and Functions of Extracellular Small RNAs in Human Circulation. Annu. Rev. Nutr. 36, 301-36. http://dx.doi.org/10.1146/annurev-nutr-071715-050711
Ghosal A. Peptide nucleic acid opens an avenue of developing novel antibacterial molecules. J. Infect. Dev. Ctries. in press.
Ghosal A. 2012.Novel antibacterial agents (antibiotics) based on RNA interference using Peptide Nucleic Acid (PNA). University of Copenhagen. http://dx.doi.org/193097359.
Ghosal A, Nielsen PE. 2012.Potent antibacterial antisense peptide–peptide nucleic acid conjugatesagainst Pseudomonas aeruginosa. Nucleic Acid Ther. 22(5), 323–34. http://dx.doi.org/10.1089/nat.2012.0370
Ghosal A, Vitali A, Stach JE, Nielsen PE. 2013. Role of SbmA in the uptake of peptide nucleic acid (PNA)-peptide conjugates in E. coli. ACS Chem. Biol. 8(2), 360–7. http://dx.doi.org/10.1021/cb300434e
Ghosal A, Upadhyaya BB, Fritz JV, Heintz-Buschart A, Desai MS, Yusuf D, Huang D, Baumuratov A, Wang K, Galas D, Wilmes P. 2015. The extracellular RNA complement of Escherichia coli. Microbiologyopen. 4(2),252–266. http://dx.doi.org/10.1002/mbo3.235
Good L, Nielsen PE. 1998. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat. Biotechnol. 16(4), 355–8. http://dx.doi.org/10.1038/nbt0498-355
Good L, Awasthi SK, Dryselius R, Larsson O, Nielsen PE. 2001. Bactericidal antisense effects ofpeptide–PNA conjugates. Nat. Biotechnol. 19(4), 360–364. http://dx.doi.org/10.1038/86753
Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, Mielcarz DW, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA.2016. A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles. PLOS Pathog. 12(6), e1005672. http://dx.doi.org/10.1371/journal.ppat.1005672
Lewis K.2013. Platforms for antibiotic discovery. Nat. Rev. Drug Discov 12(5), 371–87. http://dx.doi.org/10.1038/nrd3975
Montagner G, Bezzerri V, Cabrini G, Fabbri E, Borgatti M, Lampronti I, Finotti A, Nielsen PE, Gambari R. 2017. An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system. Int. J. Biol. Macromol. S0141-8130(16),30671-7 http://dx.doi.org/10.1016/j.ijbiomac.2017.02.011
Tan XX, Actor JK, Chen Y. 2005. Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: proof of principle using mouse intraperitoneal infection. Antimicrob Agents Chemother 49(8), 3203–7. http://dx.doi.org/10.1128/AAC.49.8.32033207.2005
Anubrata Ghosal (2017), Is antibacterial PNA the answer for combating multidrug resistant bacterial infections?; IJB, V10, N1, January, P408-410
https://innspub.net/is-antibacterial-pna-the-answer-for-combating-multidrug-resistant-bacterial-infections/
Copyright © 2017
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0