Paper Details

Lack of association between a polymorphic CA repeat in the DISC1 gene and autism in the Tunisian population

Nadia Bayou, Afaf Tiar, Ahlem Belhaj, Oussama Sidhom, M. Bechir Helayem, Ridha M’rad

DOI: https://dx.doi.org/10.12692/ijb/6.6.97-101

Int. J. Biosci. 6(6), 97-101. March, 2015. (PDF)

Abstract:

Previous studies have revealed inconsistent findings regarding the association between the Disrupted in Schizophrenia 1 (DISC1) gene and autism. Our study aimed to replicate the genetic association of the introgenic microsatellite D1S2709 of the DISC1 gene with autism in a sample of Tunisian autistic patients using the Transmission Disequilibrium Test (TDT). We did not find significant differences of allelic and genotypic frequency distribution of the D1S2709 marker between the autism and parent groups. The genotyping revealed one novel allele no described in the literature. Our findings suggest that the DISC1 gene is unlikely a major susceptible gene for autism in an ethnic Tunisian population.