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Lychee Honey-Mediated Synthesis and Characterization of Maghemite Nanoparticles: A Novel Approach for Potential Cancer Hyperthermia Applications

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Research Paper 10/10/2024
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Lychee Honey-Mediated Synthesis and Characterization of Maghemite Nanoparticles: A Novel Approach for Potential Cancer Hyperthermia Applications

Md. Anwarul Kabir Bhuiya, Md. Shahnawaz Parvez, Md. Saiful Islam, MD. Musfiqul Islam Prince, Tanvir Saklan, Md. Nahid Hasan, Md. Asadul Islam, Samia Tabassum, Md. Ahasanur Rabbi
Int. J. Biosci.25( 4), 228-238, October 2024.
Certificate: IJB 2024 [Generate Certificate]
Key: Cancer hyperthermiaGreen synthesisLychee honeyMaghemite nanoparticlesSuperparamagnetic propertiesSustainable nanotechnology

Abstract

Iron oxide nanoparticles, specifically magnetite (-NPs), have become widely used and a significant area of research due to their superparamagnetism and distinctive properties. As a result, scientists are diligently looking into new uses for these nanoparticles. The choice and use of synthesis techniques are important variables that can affect the size and characteristics of the nanoparticles (NPs). The use of toxic chemicals that are absorbed on the surface of the nanoparticles has been linked to a number of negative effects of chemical synthesis methods. The Green synthesis of nanoparticles has emerged as an eco-friendly method in response to environmental concerns, giving researchers the chance to worldwide investigate the potential of various herbs for nanoparticle synthesis. Green synthesis is considered as a novel, rapid, and eco-friendly method for obtaining metallic nanoparticles (NPs). This study presents a novel and sustainable approach to synthesizing maghemite (γ-Fe2O3) nanoparticles using Lychee honey as a natural reducing and stabilizing agent. The green synthesis method eliminates the need for toxic chemicals, aligning with the principles of eco-friendly nanotechnology. The synthesized nanoparticles were characterized using a suite of techniques to confirm their structural, optical, thermal, and magnetic properties. Fourier Transform Infrared Spectroscopy (FTIR) identified functional groups from Lychee honey responsible for particle stabilization. Differential Thermal Analysis–Thermogravimetric Analysis (DTA-TGA) assessed thermal stability, while Ultraviolet-Visible (UV-Vis) Spectroscopy confirmed nanoparticle formation. Field Emission Scanning Electron Microscopy (FESEM) revealed uniform morphology and size, and Vibrating Sample Magnetometry (VSM) demonstrated superparamagnetic behavior, suggesting suitability for biomedical applications. These findings indicate that the synthesized nanoparticles possess the requisite properties for potential use in cancer hyperthermia therapy. Future research will focus on in vivo and in vitro studies to validate their clinical applicability. This work underscores the potential of green synthesis in advancing nanotechnology for sustainable and biomedical applications.

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