Lychee Honey-Mediated Synthesis and Characterization of Maghemite Nanoparticles: A Novel Approach for Potential Cancer Hyperthermia Applications
Paper Details
Lychee Honey-Mediated Synthesis and Characterization of Maghemite Nanoparticles: A Novel Approach for Potential Cancer Hyperthermia Applications
Abstract
Iron oxide nanoparticles, specifically magnetite (-NPs), have become widely used and a significant area of research due to their superparamagnetism and distinctive properties. As a result, scientists are diligently looking into new uses for these nanoparticles. The choice and use of synthesis techniques are important variables that can affect the size and characteristics of the nanoparticles (NPs). The use of toxic chemicals that are absorbed on the surface of the nanoparticles has been linked to a number of negative effects of chemical synthesis methods. The Green synthesis of nanoparticles has emerged as an eco-friendly method in response to environmental concerns, giving researchers the chance to worldwide investigate the potential of various herbs for nanoparticle synthesis. Green synthesis is considered as a novel, rapid, and eco-friendly method for obtaining metallic nanoparticles (NPs). This study presents a novel and sustainable approach to synthesizing maghemite (γ-Fe2O3) nanoparticles using Lychee honey as a natural reducing and stabilizing agent. The green synthesis method eliminates the need for toxic chemicals, aligning with the principles of eco-friendly nanotechnology. The synthesized nanoparticles were characterized using a suite of techniques to confirm their structural, optical, thermal, and magnetic properties. Fourier Transform Infrared Spectroscopy (FTIR) identified functional groups from Lychee honey responsible for particle stabilization. Differential Thermal Analysis–Thermogravimetric Analysis (DTA-TGA) assessed thermal stability, while Ultraviolet-Visible (UV-Vis) Spectroscopy confirmed nanoparticle formation. Field Emission Scanning Electron Microscopy (FESEM) revealed uniform morphology and size, and Vibrating Sample Magnetometry (VSM) demonstrated superparamagnetic behavior, suggesting suitability for biomedical applications. These findings indicate that the synthesized nanoparticles possess the requisite properties for potential use in cancer hyperthermia therapy. Future research will focus on in vivo and in vitro studies to validate their clinical applicability. This work underscores the potential of green synthesis in advancing nanotechnology for sustainable and biomedical applications.
Kobayashi T. 2011. Cancer hyperthermia using magnetic nanoparticles. Biotechnology Journal 6(11), 1342–1347.
Fernández-Álvarez F. 2021. Engineering of stealth nanocomposites for MRI and hyperthermia against cancer. Journal of Materials Chemistry B, 9(24), 4963–4980.
Yadav VK, Fulekar MH. 2018. Biogenic synthesis of maghemite nanoparticles. Materials Today: Proceedings 5(9), 20704–20710.
Múzquiz-Ramos EM. 2015. Synthesis and characterization of maghemite nanoparticles for hyperthermia applications. Ceramics International, 41(1), 397–402.
Sangaiya P, Jayaprakash R. 2018. A review on iron oxide nanoparticles and their biomedical applications. Journal of Superconductivity and Novel Magnetism 31(11), 3397–3413.
Philip D. 2010. Honey-mediated green synthesis of silver nanoparticles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 75(3), 1078–1081.
Schwaminger SP. 2020. Controlled synthesis of magnetic iron oxide nanoparticles: Magnetite or maghemite? Crystals 10(3), 214.
Nikiforov VN. 2017. Size and surface effects on the magnetism of magnetite and maghemite nanoparticles. Journal of Experimental and Theoretical Physics 124, 304–310.
Rasouli E. 2018. Ultrasmall superparamagnetic Fe₃O₄ nanoparticles: Honey-based green synthesis and viability assay. International Journal of Nanomedicine 13, 6903–6911.
Bali Ogholbey A. 2018. Cytotoxicity characteristics of green-assisted synthesized super paramagnetic maghemite nanoparticles. Journal of Materials Science: Materials in Electronics, 29, 12135–12143.
Nadaroglu H, Güngör AA, Ince S. 2017. Synthesis of nanoparticles by green synthesis method. International Journal of Innovative Research and Reviews 1(1), 6-9.
Grazyna BP. 2009. Nanoparticles: Their potential toxicity, waste and environmental management. Waste Management 29(9), 2587–2595.
Pisane KL. 2017. Enhancement of magnetic anisotropy with decreasing particle size in maghemite nanoparticles. Applied Physics Letters, 110(22).
Bahari N. 2023. Role of honey as a bifunctional reducing and capping agent in nanotechnology. Nanomaterials 13(7), 1244.
Bonsignore G. 2021). “Green” biomaterials: The promising role of honey. Journal of Functional Biomaterials 12(4), 72.
Markova IN, Zahariev IZ, Milanova VL, Ivanova DI, Piskin MB, Fachikov LB, &Hristoforou E. 2017. Nanomaterials based on intermetallic (Co-Sn, Ni-Sn, Co-Ni) nanoparticles studied by ftir spectroscopy. Reviews on Advanced Materials Science 52(1–2), 70-81.
Kumar CG, Mamidyala SK, Sreedhar B, Reddy BV. 2011. Synthesis and characterization of gold glyconanoparticles functionalized with sugars of sweet sorghum syrup. Biotechnology progress 27(5), 1455-1463.
Santos CM, da Silva SW, Guilherme LR, Morais PC. 2011. SERRS study of molecular arrangement of amphotericin B adsorbed onto iron oxide nanoparticles precoated with a bilayer of lauric acid. The Journal of Physical Chemistry C, 115(42), 20442-20448.
Biswas N, Thomas S, Sarkar A, Mukherjee T, Kapoor S. 2009. Adsorption of methimazole on silver nanoparticles: FTIR, Raman, and surface-enhanced Raman scattering study aided by density functional theory. The Journal of Physical Chemistry C, 113(17), 7091-7100.
Stoia M, Istratie R, &Păcurariu C. 2016. Investigation of magnetite nanoparticles stability in air by thermal analysis and FTIR spectroscopy. Journal of Thermal Analysis and Calorimetry 125, 1185-1198.
Bali Ogholbeyg A, Kianvash A, Hajalilou A, Abouzari-Lotf E, Zarebkohan A. 2018. Cytotoxicity characteristics of green assisted-synthesized superparamagnetic maghemite (γ-Fe 2 O 3) nanoparticles. Journal of Materials Science: Materials in Electronics 29, 12135-12143.
Shabatina TI, Vernaya OI, Shabatin VP, Melnikov MY. 2020. Magnetic nanoparticles for biomedical purposes: Modern trends and prospects. Magneto chemistry 6(3), 30.
Rodriguez AFR, Rocha CO, Piazza RD, Dos Santos CC, Morales MA, Faria FSEDV, Marques RFC. 2018. Synthesis, characterization and applications of maghemite beads functionalized with rabbit antibodies. Nanotechnology 29(36), 365701.
Md. Anwarul Kabir Bhuiya, Md. Shahnawaz Parvez, Md. Saiful Islam, MD. Musfiqul Islam Prince, Tanvir Saklan, Md. Nahid Hasan, Md. Asadul Islam, Samia Tabassum, Md. Ahasanur Rabbi, 2024. Lychee Honey-Mediated Synthesis and Characterization of Maghemite Nanoparticles: A Novel Approach for Potential Cancer Hyperthermia Applications. Int. J. Biosci., 25(4), 228-238.
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