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Maternal blood lead levels and risk for low birth weight: a case-control study, Sidi Bel Abbes, Algeria

Moussaoui Faiza, Demmouche Abbassia, Mendai Noreddine, Bouhadiba Hadjer, Mai Hichem, Ferrag Dalila, Bouazza Sofiane, Zine Charaf Khalloua , Benali Amina, Bouaoud Khaoula, Bensaid Ilies, Talha Kheira

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Int. J. Biosci.15(3), 15-22, September 2019

DOI: http://dx.doi.org/10.12692/ijb/15.3.15-22


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Several epidemiological studies have investigated high lead (Pb) exposure and pregnancy outcomes, but few studies have investigated the association of low lead exposure and low birth weight (LBW). The aims of this study were to estimate the maternal blood lead levels (BLL), to identify determinants for BLL among parturient woman and to evaluate the association of maternal BLL and LBW. From July 2017 to February 2018, we carried out a case-control study in the genecology and obstetrics hospital of Sidi Bel Abbes, Algeria. Lead concentrations in maternal blood samples collected at delivery were measured in 29mother who delivered term LBW cases group and 29mother who give birth to a term normal weight baby matched controls.Blood lead levels were analyzed by inductively coupled plasma mass spectrometry. Mean maternal BLLwere higher among normal groups than in mothers of LBW, but this difference was not significant (23,076 ±16,120, versus 18,086 ± 6,641 ug/l p=0.247).Our results indicate that the mean lead level was not higher in LBW neonates, and the whole blood lead was not related to the birth weight. In addition,there was interaction of daily kohl use and maternal BLL. This study suggests that maternal BLL was not significantly associated with LBW. Mothers with daily use of kohl during pregnancy were more likely to have elevated blood lead concentrations.


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Maternal blood lead levels and risk for low birth weight: a case-control study, Sidi Bel Abbes, Algeria

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