Maximal oxygen consumption in response to aerobic exercise program and its relation to insulin action in diabetic patients
Paper Details
Maximal oxygen consumption in response to aerobic exercise program and its relation to insulin action in diabetic patients
Abstract
Obesity is related to chronic diseases such as syndrome metabolic and type II diabetic. The aims of present study were 1) to evaluate effect long term aerobic exercise on physical fitness and some marker indicator of type II diabetic in healthy obese men, 2) to determine relation between the change pattern of aerobic capacity and the other mentioned variables in response to this aerobic exercise program. For this purpose, a total thirty adult obese males participated in this study and were randomly divided into experimental or control groups. The experimental group subjects were participated in an aerobic exercise program (3 months / 3 times weekly) and control group did not participate in any exercise session. Aerobic capacity, fasting insulin and glucose were measured in two separate occasions in each 2 groups (before and after aerobic program). Insulin resistance was calculated with fasting glucose and insulin. Statistical analysis was performed using an independent paired t-test. Pearson correlation was used to establish the relationship between the changes pattern between variables in response to exercise program. Aerobic training program resulted in significant increase in aerobic capacity (VO2max) and significant decrease in insulin resistance and fasting glucose in experimental group. The change in VO2max was inversely associated with the change in fasting glucose and directly associated with the change in beta cell function. These data highlight that cardiovascular or physical fitness response to aerobic exercise training is independent of glucose homeostasis and insulin action in obese subjects. Further studies are needed to clarify possible mechanisms between these variables in response to exercise training.
Bloem CJ, Chang AM. 2008. Short-Term Exercise Improves B- Cell Function and Insulin Resistance in Older People with Impaired Glucose Tolerance. J Clin Endocrinol Metab 93(2), 387-92.
Chang AM, Halter JB. 2003. Aging and insulin secretion. Am J Physiol Endocrinol Metab 284, 7– 12.
Chang AM, SmithMJ, Galecki AT. 2006. Impaired B-cell function in human aging: response to nicotinic acid-induced insulin resistance. J Clin Endocrinol Metab 91(9), 3303–9.
Dela F, von Linstow ME, Mikines KJ, Galbo H. 2004. Physical training may enhance ß-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab 287(5), 1024-31.
Dietz WH. 1998.Childhood weight affects adult morbidity and mortality. J Nutr 128(2), 411-14.
Eizadi M, Somayeh B, Payman A, Davood K. 2011. Relationship between the Changes Pattern of Aerobic Capacity and Fasting Glucose in Response to Chronic Exercise Training. Advances in bioresearch 2(2), 151-155.
Eliakim A, Scheett TP, Newcomb R. 2001. Fitness, training, and the growth hormone insulin-like growth factor I axis in prepubertal girls. J Clin Endocrinol Metab 86(6), 2797-802.
Halabchi F, Hassabi M, Mazaheri R, Angoorani H. 2006. Exercise and Diseases. TUMS Sports Medicine Research Center 11, 1-36.
Hu FB, Sigal RJ, Rich-Edwards JW, Colditz GA, Solomon CG, Willett WC, Speizer FE, and Manson JE. 1999. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 282, 1433– 1439.
Hu G, Rico-Sanz J, Lakka TA, Tuomilehto J. 2006. Exercise, Genetics and Prevention of Type 2 Diabetes. Essays Biochem 42, 177-92.
Hu G, Tuomilehto J, Silventoinen K, Barengo NC, Peltonen M, Jousilahti P. 2005. The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women. Int J Obes Relat Metab Disord 8, 894-902.
Kaastra B, Manders RJ, Van Breda E, Kies A, Jeukendrup AE, Keizer HA. 2006. Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc 38(2), 268–75.
Kadoglou NP, Iliadis F, Angelopoulou N. 2007. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. Eur J Cardiovasc Prev Rehabil 14(6), 837-43.
Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, and Speizer FE. 1991. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338, 774–778.
Myers J, Kaykha A, George S. 2004. Fitness versus physical activity patterns in predicting mortality in men. Am J Med 117, 912-918.
Travers R, Dufour S, Petersen KF. 2002. Assessment of skeletal muscle triglyceride content by 1h nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51(4), 1022-7.
Travers SH, Labarta JI, Gargosky SE. 1998. Insulin-like growth factor binding protein-I levels are strongly associated with insulin sensitivity and obesity in early pubertal children. J Clin Endocrinol Metab 83(6), 1935-9.
Urano Y, Sakurai T, Ueda H. 2004. Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats. Metabolism 53(11), 1424–32.
Eizadi M, Dooaly H, Kiani F, Khorshidi F, 2013. Maximal oxygen consumption in response to aerobic exercise program and its relation to insulin action in diabetic patients. J. Biodiv. Environ. Sci., 3(1), 110-115.
Copyright © 2013 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.