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Moderate exercise test is not associated with recovery response of IL-1ß in smokers

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Research Paper 01/03/2013
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Moderate exercise test is not associated with recovery response of IL-1ß in smokers

Aghazadeh Javad, Maleki Behnam, Shirvani Hossein, Shahriary Behnam
J. Bio. Env. Sci.3( 3), 37-42, March 2013.
Certificate: JBES 2013 [Generate Certificate]
Key: ExerciseInterleukin-1 betaSmoking

Abstract

Relationship between cigarette smoking and increased morbidity and mortality has already been reported in previous studies. Fifteen healthy untrained smoker males and fifteen non-smokers matched for age, gender, height, and BMI were recruited for this study by accessible sampling. Fasting blood samples were collected of all participants for measuring and comparing serum IL-1b between smoker and non-smokers at baseline. Then, all smokers were completed an exercise test for 35 min running on smooth surface without slope at 75% of maximal heart rate. Blood sampling were repeated immediately and 60 min after stopping the test in order to determine acute and recovery response of IL-1ß to exercise in smokers. Statistical analysis was performed using an independent paired t-test. At baseline there were no differences in the age, serum IL-1b, body weight and other anthropometrical indexes between the two groups. No significant differences were found in acute and recovery serum IL-1b by exercise test with compared to baseline in smokers. This study indicates that moderate exercise test is not associated with acute or recovery response of IL-1b in smoker men. Future studies should examine the potential role of short-term exercise systemic inflammation in this population.

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Arnson Y, Shoenfeld Y, Amital H. 2010. Effects of tobacco smoke on immunity, inflammation and autoimmunity. Journal of Autoimmunity 34(3), J258.

Barbieri SS, Weksler BB. 2007. Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo. Federation of American Societies for Experimental Biology 21, 1831–1843.

Castro P, Legora-Machado A, Cardilo-Reis L, Valenca S, Porto LC, Walker C. 2004. Inhibition of interleukin-1beta reduces mouse lung inflammation induced by exposure to cigarette smoke. European Journal of Pharmacology 498, 279–286.

Chida D, Osaka T, Hashimoto O, Iwakura Y.Diabetes. 2006. Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice. Diabetes 55 (4), 971-7.

Churg A, Zhou S, Wang X, Wang R, Wright JL. 2009. The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. American Journal of Respiratory Cell and Molecular Biology 40, 482–490.

Eizadi M, Khorshidi D, Seyedhoseini MA, Dooaly H. 2011. Interleukin-1 beta response to an acute incremental cycling in obese men. Journal of Biodiversity and Environmental Sciences 1(5), 82-88.

Francis SE, Camp NJ, Dewberry RM, Gunn J, Syrris P, Carter ND. 1999. Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease. Circulation 99, 861–866.

Gery I, Gershon RK, Waksman BH. 1972. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. Journal of Experimental Medicine 136, 128–142.

Gery I,Waksman BH. 1972. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). Journal of Experimental Medicine 136, 143–155.

Goldbach-Mansky R, Dailey NJ, Canna SW. 2006. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. New England Journal of Medicine 355, 581–592.

Gomez-Merino D, Drogou C, Guezennec CY, Chennaoui M. 2007. Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats. Cytokine 40(1), 23-9.

Hart K, Haugen A, Zienolddiny S. 2008. Allele-specific induction of IL1B -31T/C promoter polymorphism by lung carcinogens. Mutation Research 656, 14–18.

Hou L, Huang J, Lu X, Wang L, Fan Z, Gu D. 2009. Polymorphisms of tumor necrosis factor alpha gene and coronary heart disease in a Chinese Han population: interaction with cigarette smoking. Thrombosis Research 123, 822–826.

Krause K, Metz M, Makris M, Zuberbier T, Maurer M. 2012. The role of interleukin-1 in allergy-related disorders. Current Opinion in Allergy and Clinical Immunology 12(5), 477-84.

Libby P, Ridker PM, Maseri A. 2002. Inflammation and atherosclerosis. Circulation 105, 1135–43.

Maedler K, Dharmadhikari G, Schumann DM, Størling J. 2009. Interleukin-1 beta targeted therapy for type 2 diabetes. Expert Opinion on Biological Therapy 9(9), 1177-88.

Martin-Cordero L, Garcia JJ, Giraldo E, De la Fuente M, Manso R, Ortega E. 2009. Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model. European Journal of Applied Physiology 107(5), 535-43.

Matsuki T, Horai R, Sudo K, Iwakura Y. 2003. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. (2003). Journal of Experimental Medicine 198(6), 877-88.

Moldoveanu AI, Shephard RJ, Shek PN. 2000. Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. Journal of Applied Physiology 89(4), 1499-504.

Oda K, Tanaka N, Arai T, Araki J, Song Y, Zhang L. 2007. Polymorphisms in pro- and anti- inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases. Human Molecular Genetics 16, 592–599.

Ozen S, Bilginer Y, Aktay Ayaz N, Calguneri M. 2011. Antiinterleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine. Journal of Rheumatology 38, 516–518.

Ross R. 1999. Atherosclerosis-an inflammatory disease. New England Journal of Medicine 340, 115– 26.

Rowsey PJ, Metzger BL, Carlson J, Gordon CJ. 2009. Long-term exercise training selectively alters serum cytokines involved in fever. Biological Research for Nursing 10(4), 374-80.

Ryder MI, Saghizadeh Ml. 2002. Effects of tobacco smoke on the secretion of interleukin-1beta, tumor necrosis factor-alpha, and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiology and Immunology 17(6), 331-6.

Sbarsi I, Falcone C, Boiocchi C, Campo I, Zorzetto M, De Silvestri A. 2007. Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease. International journal of immunopathology and pharmacology 20, 145–154.

Silvia SB, Elena Z, Patrizia A, Sara G, Luciana M, Babette BW. 2011. Cytokines present in smokers’ serum interact with smoke components to enhance endothelial dysfunction. Cardiovascular Research 90(3), 475-483.

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