Neem-natural contraceptive for male and female-an overview

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Review Paper 01/08/2011
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Neem-natural contraceptive for male and female-an overview

Jyotsna A Saonere Suryawanshi
Int. J. Biomol. & Biomed.1( 2), 1-6, August 2011.
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Neem has been used traditionally as a medicine for various ailments. It has been reported to possess wound healing, antiviral, antiarthritic, anti-hyper glycemic and anti-inflammatory properties and also help in curing skin diseases. A novel use of neem (Azadirachta indica) oil, Neem leaf extracts a traditional plant product, for long-term and reversible blocking of fertility after a single intrauterine application is described. Deshpande et al.(1980 ) have studied the anti-fertility activity.neem leaves have shown reversible male anti-fertility activity. A viginal contraceptive has also been developed from NIM-76.It is found that 3mg of neem leaf extract immobilize and kill 100% of spermatozoa within 20 seconds. The block in fertility was, however, reversible as half of the animals regained fertility and delivered normal litters by five months after treatment, without any apparent teratogenic effects. Neem oil appears to be a safe and very effective contraceptive, pre and post coital (before and after sex). The way it was applied in the studies it was 100% effective in preventing pregnancies. During in vitro experiments, neem oil also totally immobilized sperm cells within 20 to 30 seconds of being in contact with neem oil. But as we know now, this didn’t spread around the world as predicted. Population is the main problem worldwide today it is necessary to control it on time. To increase the use of neem as contraceptive this review entitled the detail study of ant fertility activity of neem which is safe and effective without producing any side effect as compared to the other available contraceptive in the market.


Shakti N, Upadhyay, Charu Kaushic Talwar GP. 1990. Antifertility Effects of Neem (Azadirachta indica) Oil by Single Intrauterine Administration: A Novel Method for Contraception Biological Sciences, 242, 175-179.

DeshpandeVY, KN Mendulkar, NL Sadre.1980. Male antifertility activity of Azadirachta indica in mice. Journal of Postgraduate Medicine 26, 167-70.

Jensen JT. 2002. Male contraception.” Current Womens Health Reports 2(5), 338-45.

Lohiya NK, B Manivannan, PK Mishra, N Pathak. 2001. Vas deferens, a site of male contraception: an overview. Asian Journal of Andrology 3(2), 87-95.

National Research Council. 1992. Neem: A tree for solving global problems. National Academy Press: Washington, DC.

Randhawa NS, BS Parmar. 1996. Neem. New Age International: New Delhi, India.

Sadre NL, VY Deshpande KN, Mendulkar DH Nandal. 1983. Male antifertility activity of Azadirachta indicain different species. In Schmutterer, H, and KRS Ascher (eds.) Natural pesticides from the neem tree (Azadirachta indica A. Juss) and other tropical plants: Proceedings of the 2nd International Neem Conference. Deutsche Gesellschaft für Technische Zusammenarbeit: Roßdorf, Germany.

Upadhyay SN, S Dhawan, GP Talwar. 1993. Antifertility effects of neem (Azadirachta indica) oil in male rats by single intra-vas administration: an alternate approach to vasectomy. Journal of Andrology 14(4), 275-81.

Rajeev Seenappa. 2009. Dinkal Agro Inc: Organic for Healthy Living.

Puri HS. 1999. Neem: The Divine Tree. Azadirachta indica. Harwood Academic Publications, Amsterdam. 90-5702-348-2.

Kaushik N, Vir S. 2000. Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India; Biochemical Society Transactions 28(6), 567-574.

Vietmeyer ND, 1992. Neem: A Tree for Solving Global Problems. Report of an ad hoc panel of the Board on Science and Technology for International Development, National Research Council, Washington, DC, USA: National Academy Press. pp.71–72. ISBN 0-309-04686-6.