Nematicidal activity of the derivatives of oleanolic acid
Paper Details
Nematicidal activity of the derivatives of oleanolic acid
Abstract
In this study, four 3 O-acylated derivatives of oleanolic acid (1a-1d) have been prepared. Compounds 3-β-[2-Triflouromethylbenzoyloxy]-olean-12-en-28-oic acid (1c) and 3-β-[4-Triflouromethylbenzoyloxy]-olean-12-en-28-oic acid (1d) are new and 3-β-[Benzoyloxy]-olean-12-en-28-oic acid (1a) and 3-β-Dichloroacetoxy-olean-12-en-28-oic acid (1b) have synthesized earlier. Their nematicidal activity against root knot nematode Meloidogyne incognita was determined and compared with the standard nematicide furadan. These derivatives were characterized through UV, IR and 1H-NMR. Oleanolic acid (1) was found to be most active with 75% toxicity and among these derivatives, 2-triflouromethyl benzoyl derivative (1c) showed highest toxicity 74% at 1% concentration. This is the first report of the nematicidal activity of these derivatives of oleanolic acid.
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