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Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar

Research Paper | July 1, 2019

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Bekhedda Hadjer, Menadi Noureddine, Demmouche Abbassia, Mai Hichem, Bouaza Sofiane, Ferrag D, Bouhadiba H, Zine Khalloua CH, Argoub hayet

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Int. J. Biosci.15( 1), 432-438, July 2019

DOI: http://dx.doi.org/10.12692/ijb/15.1.432-438


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Every day we are exposed to toxic heavy metals that pose a health risk, in an invisible way. All heavy metals are naturally present in trace amounts in our environment such as Aluminum chloride (AlCl3). Heavy metals are a metal element characterized by a high density greater than 5g per cm3. They are present everywhere in the environment most often in very small quantities; They accumulate in living organisms and disturb balances and biological mechanisms accumulate in the body and cause toxic effects. They can affect the nervous system, kidney, liver, respiratory or other functions. The aim of this study was to reveal the effects of aluminum chloride (AlCl3) on the architecture of Cerebral Cortex. In our study, twenty healthy female rats were intraperitoneally administered of aluminum chloride (ALCL3) at 10 mg / kg body weight with consecutively for 5 days, 10 day, 15 day. The results showed a significant reduction in body weight. This is because aluminum has an anorectic effect. The histological study present the alterations in the brain marked tissue necrosis and cytoplasmic vacuolations and karyopyknosis of neuronal cells of the Cerebral Cortex.


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Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar

Han S, Lemire J, Appanna VP, Auger C, Castonguay ZVD. 2013. Appanna, “How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale,” Cell Biology and Toxicology 29(2), p 75–84,

Newairy AS, Salama AF, Hussien HM, Yousef MI. 2009. Propolis alleviate aluminium-induced lipid peroxidaion and biochemical parameters in male rats. Food Chem Toxicol 47(6), 1093-8.

Abbasali KM, Zhila T, Farshad N. 2005. Developmental Toxicity of aluminium from High Doses of AlCl3 in Mice. The Journal of Applied Research 5, 575-579.

Wills MR, Hewitt CD, Sturgill BC, Savory J, Herman MM. 1993. Long-term oral or intravenous aluminium administration in rabbits.I. Renal and hepatic changes. Annals Clinical and Laboratory  Science 23, 1–16.

Sahin G, Varol I, Temizer A. 1994. Determination of aluminium levels in the kidney, liver, and brain of mice treated with aluminium hydroxide. Biological Trace Element Research 41, 129–135.

Anthony J, Fadl S, Mason C, Davison A, Berry J. 1986. Absorption, deposition and distribution of dietary aluminium in immature rats: effects of dietary vitamin D3 and food-borne chelating agent Journal of Environmental Science and Health. Part B, 21, p 191-205.

Nayak P. 2002. Aluminum: impacts and disease Environ. Res., 89 p 101-115

Pavlov IP. 1927. Conditional Reflexes. Oxford University Press, London.

Veer Bala Gupta S, Anitha ML, Hegde L, Zecca R. Garruto M, Ravid R, Shankar SK, Stein R, Shanmugavelu P, Jagannatha Rao KS. 2005 Aluminium in Alzheimer’s disease: are we still at a crossroad? Celllar and Molecular Life Science 62, 143–158.

Kawahara M. 2005. Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases Journal of Alzheimer’s Disease 8, p 171-182.

Miu ACCE, Andreescu R, Vasiu AI, Oltean UA. 2003. Behavioral and histological study of the effects of long-term exposure of adult rats to aluminum International Journal of Neuroscience 113, p 1197-1211.

Walton Brain JR. 2009. Lesions comprised of aluminum-rich cells that lack microtubules may be associated with the cognitive deficit of Alzheimer’s disease Neurotoxicology 30, p 1059-1069.

Perazella M, Brown E. 1993. Acute aluminum toxicity and alum bladder irrigation in patients with renal failure American Journal Kidney Diseases, 21 p 44-46

Berend K, Van der Voet WH. 2001.  Boer Acute aluminum encephalopathy in a dialysis center caused by a cement mortar water distribution pipe Kidney International, 59 p 746-753.

Forrester TM, Yokel RA. 1985. Comparative toxicity of intracerebroventricular and subcutaneous aluminum in the rabbit Neurotoxicology, 6, p 71-80

Kumar S. 1998. Biphasic effect of aluminium on cholinergic enzyme of rat brain Neuroscience Letters Journal 248, p 121-123

El-Sayed WM, Al-Kahtani MA, Abdel-Moneim AM. 2011. Prophylactic and therapeutic effects of taurine against aluminum-induced acute hepatotoxicity in mice, 192 p 880-886.

Oteiza PI, Keen CL, Han B, Golub MS.  1993. Aluminum accumulation and neurotoxicity in Swiss-Webster mice after long-term dietary exposure to aluminum and citrate Metabolism 42, p 1296-1300.

Zattal PF, Nicolini M, Corain B. 1991. Aluminium (III) Toxicity and Blood-brain Barrier Permeability: IN Aluminium in Chemistry Biology and Medicine Cortina International. Verona and Reven Press, New York, p 97-112.

Pohl HR, Roney N, Abadin HG.  2011. Metal ions affecting the neurological system metal Ions Life Science 8, p 247-262.

Verstraeten SV, Aimo L, Oteiza PI. 2008. Aluminium and lead: molecular mechanisms of brain toxicity Arch. Toxicol 82, p 789-802.

Wasi S, Tabrez S, Ahmad M. 2013. “Toxicological effects of major environmental pollutants: an overview,” Environmental Monitoring and Assessment 185(3), p 2585–2593.

Brodal S. 1992. The Central Nervous System: Structure and Function. Oxford University Press, Oxford. Cowling, S.J., A.M. Gunn and D.A. Winnard, 1991. Aluminium Speciation in drinking water. Report no. FRO192.

Cauller L. 1995. Layer I of primary sensory neocortex: where top-down converges upon bottom-up. Behavioral Brain Research 71(1-2), 163-70. PMID 874718.

Buraimoh AA, Ojo SA. 2012b. Effects of Aluminium Chloride Exposure on the Histology of the Stomach of Wistar Rats. International Journal of Pharm and Bio Science Oct-Dec. 2(4), 266-276

Crapper DR, Quittkat SS, Krishman Dalton AJ, De Boni U. 1980. Intranuclear aluminum content in Alzheimer’s disease, dialysis encephalopathy and experimental aluminum encephalopathy acta Neuropathology 50, 19-24.

Muller G, Bernuzzi V, Desor D, Hutin MF, Burnel D, Lher PR. 1990. Developmental alteration in offspringoffemalerats orally intoxicated by aluminum lactate at different gestation periods. Teratol 42, 253-261.

Han S. Lemire J, Appanna VP, Auger C, Castonguay Z, Appanna VD. 2013. “How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale,” Cell Biology and Toxicology 29(2), p 75–84,

Miguel Chin-Chan, Juliana Navarro-Yepes, Betzabet Quintanilla-Vega. 2015. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases 9, 124.

Terry RD, Pena C. 1965. Experimental production of neurofibrillary degeneration. Neuropath. Exp. Neurol. 24, 200–210.