Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar
Paper Details
Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar
Abstract
Every day we are exposed to toxic heavy metals that pose a health risk, in an invisible way. All heavy metals are naturally present in trace amounts in our environment such as Aluminum chloride (AlCl3). Heavy metals are a metal element characterized by a high density greater than 5g per cm3. They are present everywhere in the environment most often in very small quantities; They accumulate in living organisms and disturb balances and biological mechanisms accumulate in the body and cause toxic effects. They can affect the nervous system, kidney, liver, respiratory or other functions. The aim of this study was to reveal the effects of aluminum chloride (AlCl3) on the architecture of Cerebral Cortex. In our study, twenty healthy female rats were intraperitoneally administered of aluminum chloride (ALCL3) at 10 mg / kg body weight with consecutively for 5 days, 10 day, 15 day. The results showed a significant reduction in body weight. This is because aluminum has an anorectic effect. The histological study present the alterations in the brain marked tissue necrosis and cytoplasmic vacuolations and karyopyknosis of neuronal cells of the Cerebral Cortex.
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Bekhedda Hadjer, Menadi Noureddine, Demmouche Abbassia, Mai Hichem, Bouaza Sofiane, Ferrag D, Bouhadiba H, Zine Khalloua CH, Argoub hayet (2019), Neurotoxicity of heavy metals (aluminum chloride) studies performed on rats wistar; IJB, V15, N1, July, P432-438
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