Non-surgical management of uterine fibroids with a classical siddha formulation, Rasaganthi Mezhugu – an open pilot trial

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Research Paper 03/10/2023
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Non-surgical management of uterine fibroids with a classical siddha formulation, Rasaganthi Mezhugu – an open pilot trial

Shyamala Rajkumar, A. Faridha, Eugene Wilson, M. Kannan4, S. Vinayak
Int. J. Biosci.23( 4), 28-37, October 2023.
Certificate: IJB 2023 [Generate Certificate]

Abstract

Uterine fibroids are the most common non-cancerous growth among women of reproductive age and elderly women, and this is highly concerned with affecting women’s quality of life. The treatment procured in conventional medicine is of either medicinal management or surgical, which may lead to several complications. As a matter of considering the limitations of other conventional management, Rasaganthi Mezhugu (RGM), a classical Siddha formulation, has been selected to validate its clinical role in the management of Karuppai Sathai Kattigal/ Karuppai Naarthasai Kattigal (Uterine Fibroids). The objective of this study was to determine the safety and efficacy of RGM in patients with uterine fibroids. The study was designed as an open pilot single-arm clinical trial with a sample size of 20 patients. Women aged 25-55 years with clinical symptoms of uterine fibroids and the presence of fibroids confirmed with Trans-vaginal Ultra sonogram were included in the study. The trial drug, RGM was administered orally in 500 mg capsule twice a day for a period of 90 days and followed up at month 6 and month 9. Among 20 patients, complete disappearance of Intramural fibroids was noted in 7 patients (35%) and there was a positive significant difference in the size of fibroids from baseline compared to day 90, month 6 and month 9 at a 5% level of significance. The patients were also symptomatically relieved. Also, there were no significant differences observed in the haematological indexes of the recruited subjects, substantiating the safety profile.

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