Nonpharmologicl effect of exercise on systemic inflammation and respiratory functional in asthma patients
Paper Details
Nonpharmologicl effect of exercise on systemic inflammation and respiratory functional in asthma patients
Abstract
Accumulating evidence has described a positive association between asthma and systemic inflammation. The aims of present study were 1) to compare serum C-reactive protein and respiratory functional between asthma and non-asthma subjects, 2) to determine of acute responses of these variables to a exercise test in asthma patients . For this purpose, a spirometry test and venous blood samples were obtained of 15 adult men with asthma and those without asthma matched for age and sex. Then, these measurements were repeated in asthma patients immediately after a stepwise cycling test. At baseline, serum CRP levels were significantly higher in asthma patients in comparison to healthy subjects. Also, FEV, FVC, FEV/FVC and the other spirometry parameters were lower in asthma patients in comparison to healthy subjects at baseline. No significant differences were found in serum CRP by cycling exercise with compared to baseline in studied patients. Exercise test increased respiratory functional markers (FEV, FVC, FEV/FVC and …) in studied patients. Although exercise even for a session improves respiratory functional in asthma patients, but is not accompanied with a improving in systemic inflammation in these patients.
Albert MA, Glynn RJ, Ridker PM. 2003. Effect of physical activity on serum C-reactive protein. Am J Cardiol 93, 221- 5.
Amina H, Abdul G, Abdul K, Jasim M .2010. Association Between C Reactive Protein and Asthma. TurkishTorax Dergisi 11(3), 098 -104.
Barnes PJ, Chowdhury B, Kharitonov SA, Magnussen H, Page CP, Postma D, Saetta M. 2006. Pulmonary biomarkers in COPD. Am J Respir Crit Care Med 174, 6–14.
Church TS, Barlow CE, Earnest CP. 2002. Associations between cardiorespiratory fitness and C-reactive protein in men. Arterioscler Thromb Vasc Biol 22, 1869- 76.
Courteix D, Obert P, Lecoq AM, Guenon P, Koch G. 1997. Effect of intensive swimming training on lung volumes, airway resistance and on the maximal expiratory flow-volume relationship in prepubertal girls. Eur J Appl Physiol Occup Physiol 76(3), 264- 9.
Eizadi M, Somayeh B, Payman A, Davood K. 2011. Does systemic inflammation and allergen-specific IgE are related to each other in presence asthma. International Journal of Biosciences 1(5), 89-94.
Eizadi M, Somayeh B, Payman A, Davood K. 2011. A study of high-sensitivity C-reactive protein in relation to respiratory symptoms in mild to moderate asthma. International Journal of Biosciences 1(5), 83-88.
Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Antó JM. 2007. Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort study. Am J Respir Crit Care Med 175 (5), 458- 63.
Jousilahti P, Salomaa V, Hakala K, Rasi V, Vantera E, Palosuo T. 2002. The association of sensitive inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol 89, 381-5.
Kony S, Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. 2004. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax 59, 892-6.
LaMonte MJ, Durstine JL, Yanowitz FG. 2002. Cardiorespiratory fitness and C-reactive protein among a tri-ethnic sample of women. Circulation 106, 403 – 6.
Mannino DM, Ford ES,Redd SC.2003. Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination. Am J Med 114, 758–762.
Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.
Neveu WA, Allard JL, Raymond DM, Bourassa LM, Burns SM, Bunn JY. 2010. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respir Res 11, 28.
O’Connor GT, Sparrow D, Weiss ST. 1995. A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. Am J Respir Crit Care Med 152, 87-92.
Pelkonen M, Notkola IL, Lakka T, Tukiainen HO, Kivinen P, Nissinen A. 2003. Delaying decline in pulmonary function with physical activity: a 25-year follow-up. Am J Respir Crit Care Med 168 (4), 494- 9.
Pfützner A, Forst T. 2006. High-sensitivity C-reactive protein as cardio-vascular risk marker in patients with diabetes mellitus. Diabetes Technol Ther 8(1), 28-36.
Rijcken BJ, Schouten JP, Xu X. 1995. Airway hyperresponsiveness to histamine associated with accelerated decline in FEV1. Am J Respir Crit Care Med 51, 1377-82.
Safiullah A, Abdulla J, Muralikrishnan G, Mohamed IB, Saira k. 2010. Association of hs-CRP with Diabetic and Non-diabetic individuals. Jordan Journal of Biological Sciences 3(1), 7-12.
Sahoo RC, Acharya PR, Noushad TH, Anand R, Acharya VK, Sahu KR. 2009. A Study of High-Sensitivity C – reactive protein in Bronchial Asthma. Indian journal of chest diseases & allied sciences 51(4), 213-6.
Schroeder EB, Welch VL, Couper D, Nieto FJ, Liao D, Rosamond WD, Heiss G. 2003. Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 158, 1171–1181.
Settin A, Zedan M, Farag M, Ezz El Regal M, Osman E. 2008. Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children. Indian J Pediatr 75(10), 1019-23.
Sin DD, Wu L, Man SF. 2005. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest 127, 1952–1959.
Sokhanguei Yahya, hajirasouli Masoud, Afsharmand Zohreh, Behbudi Laleh, 2012. Nonpharmologicl effect of exercise on systemic inflammation and respiratory functional in asthma patients. Int. J. Biosci., 2(8), 109-114.
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