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Nonpharmologicl effect of exercise on systemic inflammation and respiratory functional in asthma patients

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Research Paper 01/08/2012
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Nonpharmologicl effect of exercise on systemic inflammation and respiratory functional in asthma patients

Sokhanguei Yahya, hajirasouli Masoud, Afsharmand Zohreh, Behbudi Laleh
Int. J. Biosci.2( 8), 109-114, August 2012.
Certificate: IJB 2012 [Generate Certificate]
Key: AsthmaInflammation

Abstract

Accumulating evidence has described a positive association between asthma and systemic inflammation. The aims of present study were 1) to compare serum C-reactive protein and respiratory functional between asthma and non-asthma subjects, 2) to determine of acute responses of these variables to a exercise test in asthma patients . For this purpose, a spirometry test and venous blood samples were obtained of 15 adult men with asthma and those without asthma matched for age and sex. Then, these measurements were repeated in asthma patients immediately after a stepwise cycling test. At baseline, serum CRP levels were significantly higher in asthma patients in comparison to healthy subjects. Also, FEV, FVC, FEV/FVC and the other spirometry parameters were lower in asthma patients in comparison to healthy subjects at baseline. No significant differences were found in serum CRP by cycling exercise with compared to baseline in studied patients. Exercise test increased respiratory functional markers (FEV, FVC, FEV/FVC and …) in studied patients. Although exercise even for a session improves respiratory functional in asthma patients, but is not accompanied with a improving in systemic inflammation in these patients.

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