Outcome of patients with crimean-congo hemorrhagic fever in Peshawar, Pakistan

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Outcome of patients with crimean-congo hemorrhagic fever in Peshawar, Pakistan

Ziauddin, Inayat Ullah, Hashmat Khan, Muhammad Kashif, Adil Khan, Asma Adil, Wasim Sajjad, Ihsan Ullah, Sahib Zada
Int. J. Biosci.13( 5), 128-133, November 2018.
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Crimean-Congo Hemorrhagic Fever (CCHF) is an arthropod born zoonotic viral infection that is transmitted to humans by tick bite and contact with secretions, blood and tissues infected with the virus. CCHF is a fatal disease with mortality rate of 10-40%. This study was aimed to demonstrate the effect of Ribavirin on the outcome of patients with CCHF in a tertiary care hospital, Peshawar, Pakistan. Thirty confirmed cases of CCHF were enrolled in this cross-sectional study over a period of one year. Patients were divided into two groups based on their time of arrival to hospital. Group 1: Those who presented within 07 days of onset of disease (presented early). Group 2: Those who presented after 07 days of onset disease (presented late).Oral Ribavirin was given to all patients according to dose recommended by word health organization (WHO). Outcome in these two groups was compared. Out of 30 patients, 20 patients presented early and received concomitant Ribavirin. Among them, 18 patients recovered and 02 expired. Ten patients presented late and received concomitant Ribavirin. Among them, 02 patients recovered and 08 expired. CCHF is a deadly disease. The disease rapidly progresses to death if not treated timely. Early Ribavirin therapy significantly improves the recovery outcomes of CCHF.


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