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Pathogenesis, Diagnosis, Immune Responses and Current Treatment Strategies of Covid-19

Review Paper | May 1, 2021

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Ujalla Tanveer, Laiba Bukhari, Maheen Shafiq, Zarreen Sajjad, Sana Riaz, Saim Ahmed, Muhammad Kaleem Usman, Abdul Qadeer, Hafiz Iftikhar Hussain, Mubasher Rauf

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Int. J. Biosci.18( 5), 20-28, May 2021

DOI: http://dx.doi.org/10.12692/ijb/18.5.20-28


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An ongoing novel highly contagious pneumonia outbreak started in Wuhan, sprawling capital of central china’s province, Hubei, in late December 2019. The disease was officially named by the World Health Organization on February 12, 2020, as Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The primary host of SARS-CoV-2 is linked with bat species; however, the intermediate host is still unclear. The COVID-19 spread rapidly across the world because of person-person transmission. The SARS-CoV-2 stimulates both the cellular and humoral immunity mediated by viral-specific B and T cells. Cases of COVID-19 infection exhibit several clinical complications, for example, fever, tiredness and dry cough. Diagnosis is mostly depending on epidemiological characteristics, clinical manifestation, and a few through examining auxiliary tissues. This review has provided a brief introduction of SARS-CoV-2, pathogenesis, diagnosis, immune responses, and treatments and future perspectives.


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Pathogenesis, Diagnosis, Immune Responses and Current Treatment Strategies of Covid-19

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