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Pediatric Wilms tumor: Insights from Benghazi children hospital on case characteristics and outcome

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Research Paper 12/11/2024
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Pediatric Wilms tumor: Insights from Benghazi children hospital on case characteristics and outcome

Hajir Othman, Fatimah A. Nouh, Aimen M. Khalifa, Farag A. Elshaari
Int. J. Biosci.25( 5), 294-299, November 2024.
Certificate: IJB 2024 [Generate Certificate]
Key: Disease stageOutcomeWilms tumor

Abstract

Wilms tumor (nephroblastoma) is the most common abdominal and renal pediatric cancer, accounting for over 90% of kidney tumors in children. This study aims to enlighten the local health environment with the characteristics and outcomes of Wilms tumors affecting children treated at Benghazi Children Hospital. This retrospective, descriptive study analyzed the records of patient files between 1995 and 2023. The data included sex and age at diagnosis, associated congenital abnormalities, clinical stage, tumor size, treatment, and vital status. Statistical analysis was performed using SPSS, with categorical data compared using Chi-square or Fisher’s exact test. Among the 74 patients included in the study, the mean age was 3.7 years, with male predominance of 59.5%. Most patients presented with advanced stages of the disease, with 32.4% at stage II and 27% at stage IV. The right side was the most frequent site of the tumor lesion representing 43.2%. The overall survival rate was 90.5%, with no significant difference in outcomes based on age, sex, or side of the lesion. However, the stage of the tumor was a significant prognostic factor (P = 0.025). Wilms tumor in Benghazi predominantly affects young children under six years old, with a slight male predominance. Advanced stages at presentation make it a crucial prognostic indicator and highlight the need for raising awareness, early detection, and intervention.

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