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Pediatric Wilms tumor: Insights from Benghazi children hospital on case characteristics and outcome

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Research Paper 12/11/2024
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Pediatric Wilms tumor: Insights from Benghazi children hospital on case characteristics and outcome

Hajir Othman, Fatimah A. Nouh, Aimen M. Khalifa, Farag A. Elshaari
Int. J. Biosci.25( 5), 294-299, November 2024.
Certificate: IJB 2024 [Generate Certificate]
Key: Disease stageOutcomeWilms tumor

Abstract

Wilms tumor (nephroblastoma) is the most common abdominal and renal pediatric cancer, accounting for over 90% of kidney tumors in children. This study aims to enlighten the local health environment with the characteristics and outcomes of Wilms tumors affecting children treated at Benghazi Children Hospital. This retrospective, descriptive study analyzed the records of patient files between 1995 and 2023. The data included sex and age at diagnosis, associated congenital abnormalities, clinical stage, tumor size, treatment, and vital status. Statistical analysis was performed using SPSS, with categorical data compared using Chi-square or Fisher’s exact test. Among the 74 patients included in the study, the mean age was 3.7 years, with male predominance of 59.5%. Most patients presented with advanced stages of the disease, with 32.4% at stage II and 27% at stage IV. The right side was the most frequent site of the tumor lesion representing 43.2%. The overall survival rate was 90.5%, with no significant difference in outcomes based on age, sex, or side of the lesion. However, the stage of the tumor was a significant prognostic factor (P = 0.025). Wilms tumor in Benghazi predominantly affects young children under six years old, with a slight male predominance. Advanced stages at presentation make it a crucial prognostic indicator and highlight the need for raising awareness, early detection, and intervention.

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Abd El-Aal HH, Habib EE, Mishrif MM. 2005. Wilms’ tumor: the experience of the pediatric unit of Kasr El-Aini center of radiation oncology and nuclear medicine (NEMROCK). Journal of the Egyptian National Cancer Institute 17(4), 308–314.

Al Mulhim I. 1997. Wilm’s tumor in children: A 10-year experience from the Eastern Province of Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation: An Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia 8(2), 123–126.

Chu A, Heck JE, Ribeiro KB, Brennan P, Boffetta P, Buffler P, Hung RJ. 2010. Wilms’ tumour: a systematic review of risk factors and meta‐analysis. Paediatric and Perinatal Epidemiology 24(5), 449–469.

D’Angio GJ, Breslow N, Beckwith JB, Evans A, Baum H, deLorimier A, Fernbach D, Hrabovsky E, Jones B, Kelalis P. 1989. Treatment of Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer 64(2), 349–360.

Dénes FT, Duarte RJ, Cristófani LM, Lopes RI. 2013. Pediatric genitourinary oncology. Frontiers in Pediatrics 1, 48.

Green DM. 2004. The treatment of stages I-IV favorable histology Wilms’ tumor. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 22(8), 1366–1372.

Haddadin I, Hazza I. 2000. Wilms’ tumor experience at King Hussein Medical Center. Saudi Journal of Kidney Diseases and Transplantation: An Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia 11(1), 35–39.

Hun IJ, Chang WH, Yang CP, Jaing TH, Liang DC, Lin KH, Li DT, Hsiao CC, Hsieh YL, Chen JS, Chang TT, Peng CT, Shu SG, Lin MT, Chen BW, Lin KS, Taiwan Pediatric Oncology Group. 2004. Epidemiology, clinical features, and treatment outcome of Wilms’ tumor in Taiwan: A report from Taiwan Pediatric Oncology Group. Journal of the Formosan Medical Association = Taiwan Yi Zhi 103(2), 104–111.

Ikhuoriah T, Oboh D, Musheyev Y, Abramowitz C, Ilyaev B. 2023. Wilms tumor: A case report with typical clinical and radiologic features in a 3-year-old male. Radiology Case Reports 18(5), 1898–1904.

Ko EY, Ritchey ML. 2009. Current management of Wilms’ tumor in children. Journal of Pediatric Urology 5(1), 56–65.

Leslie SW, Sajjad H, Murphy PB. 2023. Wilms tumor. In: StatPearls (Internet). Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28723033.

Lopes RI, Lorenzo A. 2017. Recent advances in the management of Wilms’ tumor. F1000Research 6, 670.

Maher K, Mustafa M, Mufeed K, Hamoury M, Salma S, Hassan R. 2014. Wilms’ tumor in children: A single institution 10-year experience. The Egyptian Journal of Hospital Medicine 55, 159–164.

Metzger ML, Dome JS. 2005. Current therapy for Wilms’ tumor. The Oncologist 10(10), 815–826.

Rais F, Benhmidou N, Rais G, Loughlimi H, Kouhen F, Maghou A, Aarab J, Bellahammou K, Moukinebillah M, Khattab M, Chala S, Elmejjaoui S, Kebdani T, Elkacemi H, Benjaafar N. 2016. Wilms tumor in childhood: Single centre retrospective study from the National Institute of Oncology of Rabat and literature review. Pediatric Hematology Oncology Journal 1(2), 28–34.

Rančelytė M, Nemanienė R, Ragelienė L, Rascon J. 2019. Wilms tumour in children: 18 years of experience at Vilnius University Hospital Santaros Klinikos, Lithuania. Acta Medica Lituanica 26(2), 125–133.

Reinhard H, Aliani S, Ruebe C, Stöckle M, Leuschner I, Graf N. 2004. Wilms’ tumor in adults: Results of the Society of Pediatric Oncology (SIOP) 93-01/Society for Pediatric Oncology and Hematology (GPOH) Study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 22(22), 4500–4506.

Ritchey ML, Shamberger RC, Hamilton T, Haase G, Argani P, Peterson S. 2005. Fate of bilateral renal lesions missed on preoperative imaging: A report from the National Wilms Tumor Study Group. The Journal of Urology 174(4 Pt 2), 1519–1521.

Spreafico F, Bellani FF. 2006. Wilms’ tumor: Past, present and (possibly) future. Expert Review of Anticancer Therapy 6(2), 249–258.

Szychot E, Apps J, Pritchard-Jones K. 2014. Wilms’ tumor: Biology, diagnosis and treatment. Translational Pediatrics 3(1), 12–24.

Theilen TM, Braun Y, Bochennek K, Rolle U, Fiegel HC, Friedmacher F. 2022. Multidisciplinary treatment strategies for Wilms tumor: Recent advances, technical innovations and future directions. Frontiers in Pediatrics 10, 852185.

Yildiz I, Yüksel L, Ozkan A, Apak H, Celkan T, Danismend N, Büyükünal C, Söylet Y, Sarimurat N, Dervisoglu S, Aksoy F, Atkovar G, Okkan S. 2000. Multidisciplinary approach to Wilms’ tumor: 18 years of experience. Japanese Journal of Clinical Oncology 30(1), 17–20.

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