Pesticides toxicity assessment in occupational workers in Dir Lower, Khyber Pakhtunkhwa, Pakistan

Paper Details

Research Paper 01/05/2016
Views (291) Download (12)
current_issue_feature_image
publication_file

Pesticides toxicity assessment in occupational workers in Dir Lower, Khyber Pakhtunkhwa, Pakistan

Fazal Hussain, Muhammad Hussain, Sultan Ahmad, Salman Khan, Amina Zuberi, Fahim Ullah Khan, Zohaib Noor, Syed Allauddin Khan, Muhammad Sardar, Saleem Ur Rahman
Int. J. Agron. Agri. Res.8( 5), 26-31, May 2016.
Certificate: IJAAR 2016 [Generate Certificate]

Abstract

Pesticides are chemical compounds used to control insects and weeds to enhance food and crops productivity. The present study was aimed to evaluate the effects of pesticides on health status of dealers and farmers in district Dir Lower, Khyber Pakhtunkhwa, Pakistan. Blood samples were collected from different groups viz: farmers, dealers (exposed to pesticides), and control (not exposed to pesticides) and the history was recorded on a questioner. For Blood Profiling and Serum Biomarkers analysis, Sysmex Kx-21 (Japan) and Shiamadzu Double Beam Spectrophotometer 1700 Pharma (Japan) were used. Upon pesticides exposure the blood cholesterol, Triglyceride, Serum glutamate pyruvate transaminase, Uric Acid, Total Lipid, Low density lipoprotein, High density lipoprotein, Mean Corpuscular Hemoglobin Concentration, Platelets and White Blood Cells count were increased in dealers and farmers as compared to control group. While, Hemoglobin, Red Blood Cells, hematocrit, Mean Corpuscular Volume, Mean Corpuscular Hemoglobin, Lymphocytes and Neutrophils counts decreased in farmers and dealers as compared to control. The present findings suggest that pesticides exposure adversely affect dealers and farmers health status by significantly altering their liver and kidney functions as well as blood biochemistry and hematology.

VIEWS 12

Aktar W, Sengupta D, Chowdhury A. 2009. Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary Toxicology 2, 1-12. doi:org/10.2478/v10102-009-0001-7

Alpalan  G,  Kanat  HD,  Dilek  B,  Altuntas  I. 2006. Effects of diazinon at different doses on rat liver and pancreas tissues. Pesticide biochemistry and physiology 87, 103-108.

AL-Shinnawy MSAA. 2008. Effects of Orally Fed Diazinon on Some Biochemical Parameters of Male Albino Rats. The Egyptian Journal of Hospital Medicine 33, 559– 568.

Falck F, Ricci A, Wolff MS, Godbold J, Deckers P. 1992. Supplementation on Biochemical Parameters in Pesticides Sprayers of Grape Gardens of Western Maharashtra (India).Indian Journal of Clinical Biochemistry 27, 134–140. doi:org/10.1007/s12291-012-0207-x

Jasper R, Locatelli GO, Pilati C, Locatelli C. 2012. Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup. Interdisciplinary Toxicology 5, 133–140.doi:10.2478/v10102-012-0022-5

Kamel F, Hoppin JA. 2004. Association of pesticide exposure with neurologic dysfunction and disease. Environmental Health Perspectives 112, 950-958.doi:org/10.1289/ehp.7135

Kumar LP, Panneerselvam N. 2008. Toxic effects of pesticides: A review on cytogenetic biomonitoring studies. Medicine and Biology 15, 46-50.

Mnif W, Hassine AIH, Bouaziz A, Bartegi A, Thomas O, Roig B. 2011. Effect of Endocrine Disruptor Pesticides. A Review: International Journal of Environmental Research and Public Health 8, 2265-2303.doi:org/10.3390/ijerph8062265

Muralidharan L. 2012. Haemato-biochemical alterations induced by chronic exposure to fenthionin Cyprinus carpio.Trends in Fisheries Research 1, 19-25.

Muthuviveganandavel V, Muthuraman P, Muthu S, Srikumar K. 2008.Toxic effects of carbendazim at low dose levels in male rats. Journal of Toxicological Sciences 33, 25-30.

Nabi G, Urooj J, Khan AA, Zamani GY, Wahid M, Rahman SU. 2014. Effects of Occupational Exposure to Wood Smoke in Tandoor Occupants. Journal of Biology and Life Science 5, 37-47.doi:10.5296/jbls.v5i2.4079

Patil JA, Patil AJ, Sontakke AV, Govindwar SP. 2009. Effect of Vitamin E on liver and kidney function.  Journal  of  Basic  Clinical  Physiology  and Pharmacology 20, 335-55. doi:org/10.1515/JBCPP.2009.20.4.335

Salih EMA. 1995. Toxic Effect of Dimethoate and Diazinon on the Biochemical and Hematological parameters in male rabbits. Jordan Journal of Biological Sciences 3, 77-82.

Saxena P, Saxena AK. 2010. Cypermethrin Induced Biochemical Alterations in the Blood of Albino Rats. Jordan Journal of Biological Sciences 3, 111-114.

Wolfe HR, Durham WF, Armstrong JF. 1967. Exposure of workers to pesticides. Archives of Environmental Health 14, 622–33.